de Pree C, Pelte M F, Delacretaz F, Aapro M, Pugin P, Miescher P A
Clinique Médicale, Hôpital Cantonal, Fribourg, Switzerland.
Nouv Rev Fr Hematol (1978). 1990;32(4):241-7.
Histiocytic necrotizing lymphadentis (HNL) is an uncommon clinical and histologic entity, essentially diagnosed in Japan since 1972. The clinical picture is usually characterized by cervical lymphadenopathy and fever, females being more often affected. Leukopenia and elevated erythrocyte sedimentation rate are frequent. The etiology is still unknown, but a viral origin is most likely. The clinical course is always favorable without treatment, except in one case. The histological picture, with necrotic foci surrounded by histiocytes, immunoblasts, small T lymphocytes and plasmacytoid monocytes (so-called plasmacytoid T cells), is characteristic. Nevertheless, HNL may be mistaken for malignant lymphoma both clinically and histologically. We report 4 cases of HNL. One of these presented severe leukothrombopenia; the serum of this patient significantly suppressed the maturation of granulocytic precursor cells in the bone marrow.
组织细胞坏死性淋巴结炎（HNL）是一种罕见的临床和组织学疾病，自1972年以来主要在日本被诊断出来。临床表现通常以颈部淋巴结病和发热为特征，女性更常受累。白细胞减少和红细胞沉降率升高很常见。病因仍然不明，但最有可能源于病毒。除1例病例外，未经治疗的临床病程通常良好。其组织学表现为坏死灶被组织细胞、免疫母细胞、小T淋巴细胞和浆细胞样单核细胞（所谓的浆细胞样T细胞）包围，具有特征性。然而，HNL在临床和组织学上都可能被误诊为恶性淋巴瘤。我们报告了4例HNL病例。其中1例出现严重的白细胞血小板减少症；该患者的血清显著抑制了骨髓中粒细胞前体细胞的成熟。
