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颈椎全椎间盘置换术的生物力学研究:文献综述

Biomechanical studies on cervical total disc arthroplasty: a literature review.

作者信息

Galbusera Fabio, Bellini Chiara M, Brayda-Bruno Marco, Fornari Maurizio

机构信息

IRCCS Istituto Ortopedico Galeazzi, via Riccardo Galeazzi 4, 20161 Milan, Italy.

出版信息

Clin Biomech (Bristol). 2008 Nov;23(9):1095-104. doi: 10.1016/j.clinbiomech.2008.06.002. Epub 2008 Jul 16.

Abstract

BACKGROUND

Many models of cervical disc prostheses are currently commercially available or under clinical trial, and are based on several design concepts and built employing different materials. This paper is targeted to the understanding of the possible relationships between the geometrical, mechanical and material properties of the various cervical disc prostheses and the restoration of a correct biomechanics of the implanted spine.

METHODS

Papers about cervical disc arthroplasty, based on ex vivo testing, mathematical models, and radiographic measurements, were included in the present review.

FINDINGS

Although disc arthroplasty was found to be generally able to preserve a nearly physiological motion in the cervical spine, several alterations in the spine biomechanics due to disc arthroplasty were reported in the literature. An increase of the range of motion at the implanted level was observed in some ex vivo studies. Loss of mobility and heterotopic ossification were reported in radiographic investigations. Loss of lordosis at the implanted level was detected as well. Wear debris was usually found very limited and device stability seemed not to be an actual problem.

INTERPRETATION

The possible relationships between the observed alterations in the spine biomechanics after disc arthroplasty and the properties of the various cervical disc prostheses have been reviewed. Clinical studies are needed to assess the validity of the considerations inferred from the biomechanical papers.

摘要

背景

目前许多颈椎间盘假体模型已上市或正在进行临床试验,它们基于多种设计理念,采用不同材料制造。本文旨在了解各种颈椎间盘假体的几何、力学和材料特性与植入脊柱正确生物力学恢复之间的可能关系。

方法

本综述纳入了基于体外测试、数学模型和影像学测量的有关颈椎间盘置换术的论文。

结果

尽管发现椎间盘置换术通常能够在颈椎中保留接近生理的运动,但文献中报道了由于椎间盘置换术导致的脊柱生物力学的一些改变。在一些体外研究中观察到植入节段活动范围增加。影像学研究报告了活动度丧失和异位骨化。还检测到植入节段前凸丢失。磨损碎屑通常非常有限,并且器械稳定性似乎不是实际问题。

解读

本文综述了椎间盘置换术后观察到的脊柱生物力学改变与各种颈椎间盘假体特性之间的可能关系。需要进行临床研究以评估从生物力学论文中推断出的观点的有效性。

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