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镁和牛磺酸对天然及人工膜电参数影响的比较研究。VIII. 对人羊膜上皮细胞超微结构的影响

Comparative study of effects of magnesium and taurine on electrical parameters of natural and artificial membranes. VIII. Effect on the ultrastructure of human amniotic epithelial cells.

作者信息

Guiet-Bara A, Bara M, Durlach J

机构信息

Laboratory of Biology of Reproduction, University P.M. Curie, Paris, France.

出版信息

Magnes Res. 1991 Mar;4(1):35-9.

PMID:1863533
Abstract

The ultrastructure of human amniotic epithelial cells from normal pregnancies, at term, was studied using transmission electron microscopy. The results were analysed by a stereological method which indicates the ratio between the volume of the intercellular space (R1, the microvilli (R2), and the podocytes (R3) versus the cell volume. At low concentration (2 mM), MgCl2 decreased R1 and R3 and had no significant effect on R2. In contrast, taurine (2 mM) increased R1 and had no significant effect on R2 and R3. There is no vicarious action between Mg and taurine. These data are in contrast to the results obtained after electrophysiological studies, which indicates that the structural targets for Mg and taurine are different from the targets responsible for ionic transfer.

摘要

利用透射电子显微镜对足月正常妊娠的人羊膜上皮细胞超微结构进行了研究。采用体视学方法分析结果,该方法表明细胞间空间体积(R1)、微绒毛(R2)和足细胞(R3)与细胞体积的比值。在低浓度(2 mM)时,MgCl2降低了R1和R3,对R2无显著影响。相比之下,牛磺酸(2 mM)增加了R1,对R2和R3无显著影响。Mg和牛磺酸之间没有替代作用。这些数据与电生理研究结果相反,电生理研究结果表明Mg和牛磺酸的结构靶点与负责离子转运的靶点不同。

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引用本文的文献

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Nuclear microanalysis of the monovalent ions distribution in the human amnion : II. Effect of taurine.人羊膜中单价离子分布的核微分析:II. 牛磺酸的作用。
Amino Acids. 1995 Dec;9(4):353-62. doi: 10.1007/BF00807272.