Guiet-Bara A, Bara M, Durlach J
Laboratory of Biology of Reproduction, University P.M. Curie, Paris, France.
Magnes Res. 1991 Jun;4(2):77-81.
Measurement of the ratio between the volume of the intercellular space (R1), the microvilli (R2), the podocytes (R3), and the nucleus (R4) versus the cell volume indicates the effects of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) on the ultrastructure of the human epithelial cells. R1 is decreased by all toxic metals except Pb. R2 is increased by Cd and As, and decreased by Pb. R3 is not affected. R4 is increased only by As. The addition of MgCl2 to the bathing medium antagonizes the effect of Cd on the intercellular space, of Pb on the microvilli, and of As on nucleus. On the other hand, Mg enhances the effects of Pb on R1 and those of Cd and As on R2. Mg may be either a competitive inhibitor or an activator of the effects of the toxic substances examined in relation to their storage sites.
测量细胞间空间（R1）、微绒毛（R2）、足细胞（R3）和细胞核（R4）的体积与细胞体积之比，可表明铅（Pb）、镉（Cd）、砷（As）和汞（Hg）对人上皮细胞超微结构的影响。除Pb外，所有有毒金属均使R1降低。Cd和As使R2增加，Pb使R2降低。R3不受影响。仅As使R4增加。向浴液中添加MgCl2可拮抗Cd对细胞间空间、Pb对微绒毛以及As对细胞核的影响。另一方面，Mg增强了Pb对R1的影响以及Cd和As对R2的影响。Mg可能是所检测有毒物质与其储存位点相关效应的竞争性抑制剂或激活剂。
