Chamberlain Samuel R, Menzies Lara, Hampshire Adam, Suckling John, Fineberg Naomi A, del Campo Natalia, Aitken Mike, Craig Kevin, Owen Adrian M, Bullmore Edward T, Robbins Trevor W, Sahakian Barbara J
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK.
Science. 2008 Jul 18;321(5887):421-2. doi: 10.1126/science.1154433.
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
强迫症（OCD）的特征是反复出现的想法和行为，与额前叶纹状体回路的潜在失调有关。强迫症神经生物学模型的核心是眶额皮质，这是一个在负反馈（逆向学习）后促进行为灵活性的神经区域。我们发现，在强迫症患者及其临床未受影响的近亲进行逆向学习期间，包括外侧眶额皮质在内的几个皮质区域的激活异常减少，这支持了这种疾病存在一种以前未被发现的潜在内表型。
