Pamukkale University, Medicine Faculty, Department of Psychiatry, Denizli 20070, Turkey.
Pamukkale University, Medicine Faculty, Department of Psychiatry, Denizli 20070, Turkey.
Psychiatry Res. 2017 Jun;252:231-233. doi: 10.1016/j.psychres.2017.03.001. Epub 2017 Mar 6.
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investigate this hypothesis, we administered a probabilistic reversal learning task (ProbRev) to OCD patients, their unaffected first-degree relatives, and healthy controls. Although the relatives had a performance in between OCDs and controls at the early phase of the ProbRev, their performance was similar to controls and was significantly better than OCD patients at the later stages of the test. Our findings imply that reversal learning impairment might be partly a trait-related feature of OCD but state-related factors can also contribute to observed deficits.
有人提出，反转学习缺陷可能是 OCD 的一个内表型。为了验证这一假说，我们对 OCD 患者、未受影响的一级亲属和健康对照组进行了概率反转学习任务（ProbRev）。尽管亲属在 ProbRev 的早期阶段的表现介于 OCD 患者和对照组之间，但他们在测试的后期阶段的表现与对照组相似，明显优于 OCD 患者。我们的研究结果表明，反转学习损伤可能部分是 OCD 的特质相关特征，但状态相关因素也可能导致观察到的缺陷。
