Kobayashi Makoto, Hamada Tadateru, Goto Hitomi, Imaizumi Katsumi, Ikeda Ikuo
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan.
J Nutr Sci Vitaminol (Tokyo). 2008 Jun;54(3):210-4. doi: 10.3177/jnsv.54.210.
Effects of dietary unesterified plant sterols and plant sterol oleates and stearates on absorption and metabolism of cholesterol were compared in rats fed a cholesterol-supplemented diet. Fecal excretion of neutral steroids (cholesterol plus coprostanol) in rats fed unesterified plant sterols or plant sterol oleates was significantly higher than in those fed the control diet or plant sterol stearates. Deposition of cholesterol in the liver was significantly lower in rats fed unesterified plant sterols or plant sterol oleates than in those fed the control diet or plant sterol stearates. No significant difference was observed in fecal excretion of cholesterol plus coprostanol and hepatic cholesterol concentration between unesterified plant sterols and plant sterol oleates. Unesterified plant sterols were significantly more effective to reduce lymphatic recovery of radiolabeled cholesterol given to the stomach than plant sterol oleates. Although our observations suggest a possibility that unesterified plant sterols are potentially more effective to inhibit cholesterol absorption than plant sterol oleates in rats, difference in the activity is substantially small between these two forms of plant sterols.
在喂食补充胆固醇饮食的大鼠中，比较了膳食中未酯化植物甾醇、植物甾醇油酸酯和硬脂酸酯对胆固醇吸收和代谢的影响。喂食未酯化植物甾醇或植物甾醇油酸酯的大鼠中性类固醇（胆固醇加粪甾烷醇）的粪便排泄量显著高于喂食对照饮食或植物甾醇硬脂酸酯的大鼠。喂食未酯化植物甾醇或植物甾醇油酸酯的大鼠肝脏中胆固醇的沉积量显著低于喂食对照饮食或植物甾醇硬脂酸酯的大鼠。未酯化植物甾醇和植物甾醇油酸酯之间，胆固醇加粪甾烷醇的粪便排泄量和肝脏胆固醇浓度未观察到显著差异。未酯化植物甾醇比植物甾醇油酸酯在减少给予胃的放射性标记胆固醇的淋巴回收方面显著更有效。尽管我们的观察结果表明，在大鼠中未酯化植物甾醇可能比植物甾醇油酸酯在抑制胆固醇吸收方面更有效，但这两种形式的植物甾醇之间的活性差异相当小。
