Cho Young Jae, Kim Wook Kyum, Lee Jong Hyun, Byeon Suk Ho, Koh Hyoung Jun, Kwon Oh Woong, Lee Sung Chul
Siloam Eye Hospital , Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Ophthalmologica. 2008;222(5):344-50. doi: 10.1159/000146080. Epub 2008 Jul 21.
Visual prognosis was evaluated in Korean Behcet uveitis patients. The study investigated factors associated with poor visual outcome, and the effect of various treatments on recurrence-free duration.
A retrospective analysis was undertaken on 99 consecutive Behcet uveitis patients (168 eyes). Visual prognosis was evaluated using Kaplan-Meier survival curves, and Cox's proportional hazard regression analysis was used to identify risk factors.
Visual acuity at the first visit (<0.5), presence of vasculitis, male gender, and posterior/panuveitis type were associated with poor visual prognosis. Visual acuity at the first visit was found to be the most significant risk factor (hazard ratio = 7.392, p = 0.007). Analysis of 9 different treatment modalities showed patients treated with steroids had longer recurrence-free periods than those not treated with steroids (p = 0.0053, t test).
Whilethe long-term visual prognosis for Behcet uveitis may be affected by many factors, the initial visual acuity appears to be the most significant. Treatments involving steroids appear to decrease the frequency of uveitis recurrence.
评估韩国白塞氏葡萄膜炎患者的视力预后。本研究调查了与视力预后不良相关的因素，以及各种治疗方法对无复发持续时间的影响。
对99例连续的白塞氏葡萄膜炎患者（168只眼）进行回顾性分析。使用Kaplan-Meier生存曲线评估视力预后，并使用Cox比例风险回归分析来确定危险因素。
首次就诊时的视力（<0.5）、血管炎的存在、男性性别以及后葡萄膜炎/全葡萄膜炎类型与视力预后不良相关。首次就诊时的视力被发现是最显著的危险因素（风险比=7.392，p=0.007）。对9种不同治疗方式的分析表明，接受类固醇治疗的患者无复发期比未接受类固醇治疗的患者更长（p=0.0053，t检验）。
虽然白塞氏葡萄膜炎的长期视力预后可能受多种因素影响，但初始视力似乎是最显著的因素。涉及类固醇的治疗似乎可降低葡萄膜炎复发的频率。
