Rhee Ji-Young, Kwon Ki Tae, Ki Hyun Kyun, Shin Sang Yop, Jung Dong Sik, Chung Doo-Ryeon, Ha Byoung-Chun, Peck Kyong Ran, Song Jae-Hoon
Division of Infectious Diseases, Department of Medicine, Dankook University, Cheonan, Chungcheongnam-do, Republic of Korea.
Shock. 2009 Feb;31(2):146-50. doi: 10.1097/SHK.0b013e318182f98f.
This study compares the effectiveness of the Pitt bacteremia score, the Charlson weighted index of comorbidity, and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring systems for the prediction of mortality in intensive care unit (ICU) patients with sepsis using the retrospective observational method on 134 patients with ICU-acquired sepsis. The statistical analyses show several important findings. First, Pitt bacteremia score is significantly correlated with the APACHE II scoring system (correlation coefficient = 0.738, P < 0.001). Second, the APACHE II scoring system, the Pitt bacteremia score, and the Charlson weighted index of comorbidity are independently correlated with mortality. Third, the Pitt bacteremia score and the APACHE II scores are positively related to mortality in patients with ICU-acquired sepsis. As the result of the analyses, the mortality rate in patients with sepsis in the ICU is better predicted with the Pitt bacteremia score because it provides better estimation of sensitivity and specificity than the APACHE II scoring system and the Charlson weighted index of comorbidity.
本研究采用回顾性观察方法，对134例重症监护病房（ICU）获得性脓毒症患者进行研究，比较了皮特菌血症评分、查尔森合并症加权指数和急性生理与慢性健康状况评价II（APACHE II）评分系统对ICU脓毒症患者死亡率的预测效果。统计分析显示了几个重要发现。首先，皮特菌血症评分与APACHE II评分系统显著相关（相关系数=0.738，P<0.001）。其次，APACHE II评分系统、皮特菌血症评分和查尔森合并症加权指数均与死亡率独立相关。第三，皮特菌血症评分和APACHE II评分与ICU获得性脓毒症患者的死亡率呈正相关。分析结果表明，皮特菌血症评分能更好地预测ICU脓毒症患者的死亡率，因为它比APACHE II评分系统和查尔森合并症加权指数能提供更好的敏感性和特异性估计。
