Igarashi Junsuke, Michel Thomas
Department of Cardiovascular Physiology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793 Japan.
Biochim Biophys Acta. 2008 Sep;1781(9):489-95. doi: 10.1016/j.bbalip.2008.06.008. Epub 2008 Jun 27.
In the mammalian cardiovascular system, nitric oxide (NO), a small diffusible gaseous signal mediator, plays pivotal roles in the maintenance of vascular homeostasis. The endothelial isoform of nitric oxide synthase (eNOS) is activated by diverse agonist-modulated cell surface receptors, and eNOS-derived NO is a key determinant of blood pressure, platelet activation, angiogenesis and other fundamental responses in the vascular wall. Sphingosine 1-phosphate (S1P) has recently been identified as an important activator of eNOS. This review summarizes the roles of sphingosine 1-phosphate and S1P receptors in eNOS activation, and analyzes the eNOS regulatory processes evoked by S1P. The implications of S1P activation of eNOS in cardiovascular (patho)physiology will be also discussed.
在哺乳动物心血管系统中，一氧化氮（NO）作为一种可扩散的小分子气态信号介质，在维持血管稳态中发挥着关键作用。一氧化氮合酶（eNOS）的内皮型可被多种激动剂调节的细胞表面受体激活，且eNOS衍生的NO是血压、血小板活化、血管生成及血管壁其他基本反应的关键决定因素。鞘氨醇-1-磷酸（S1P）最近被确定为eNOS的重要激活剂。本综述总结了鞘氨醇-1-磷酸和S1P受体在eNOS激活中的作用，并分析了S1P引发的eNOS调节过程。还将讨论S1P激活eNOS在心血管（病理）生理学中的意义。
