Iwasaki S, Smulders Y E, Burgess A M, McGarvie L A, Macdougall H G, Halmagyi G M, Curthoys I S
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Clin Neurophysiol. 2008 Sep;119(9):2135-47. doi: 10.1016/j.clinph.2008.05.028. Epub 2008 Jul 17.
To provide the empirical basis for using ocular vestibular evoked myogenic potentials (oVEMPS) in response to Fz bone conducted vibration (BCV) stimulation to indicate vestibular function in human subjects. To show the generality of the response by testing a large number of unselected healthy subjects across a wide age range and the repeatability of the response within subjects. To provide evidence that the response depends on otolithic function.
The early negative component (n10) of the oVEMP to brief BCV of the forehead, in the midline at the hairline (Fz) is recorded by surface EMG electrodes just beneath the eyes. We used a Bruel and Kjaer 4810 Mini-Shaker or a light tap with a tendon hammer to provide adequate BCV stimuli to test a large number (67) of unselected healthy people to quantify the individual differences in n10 magnitude, latency and symmetry to Fz BCV. A Radioear B-71 bone oscillator at Fz is not adequate to elicit a reliable n10 response.
The n10 oVEMP response showed substantial differences in amplitude between subjects, but is repeatable within subjects. n10 is of equal magnitude in both eyes with an average asymmetry around 11%. The average n10 amplitude for Mini Tone Burst BCV is 8.47microV+/-4.02 (sd), the average latency is 10.35ms+/-0.63 (sd). The amplitude of n10 decreases and its latency increases with age.
oVEMPs are a new reliable, repeatable test to indicate vestibular and probably otolithic function.
This study shows the optimum conditions for recording oVEMPs and provides baseline values for individual differences and asymmetry. oVEMPs can be measured in senior subjects without difficulty.
为使用眼前庭诱发肌源性电位（oVEMPs）对额部中线发际处（Fz）骨传导振动（BCV）刺激的反应来评估人体前庭功能提供实证依据。通过对大量未经过筛选的、年龄范围广泛的健康受试者进行测试，以展示该反应的普遍性以及受试者内反应的可重复性。提供证据证明该反应依赖于耳石功能。
通过置于眼睛下方的表面肌电图电极记录前额中线发际处（Fz）对短暂BCV刺激产生的oVEMP的早期负向成分（n10）。我们使用Bruel和Kjaer 4810小型振动器或用肌腱锤轻敲来提供足够的BCV刺激，以测试大量（67名）未经过筛选的健康人，量化n10的幅度、潜伏期和对Fz BCV的对称性方面的个体差异。Fz处的Radioear B - 71骨振荡器不足以引发可靠的n10反应。
n10 oVEMP反应在受试者之间的幅度存在显著差异，但在受试者内具有可重复性。n10在双眼的幅度相等，平均不对称率约为11%。Mini Tone Burst BCV的平均n10幅度为8.47微伏±4.02（标准差），平均潜伏期为10.35毫秒±0.63（标准差）。n10的幅度随年龄增长而降低，潜伏期随年龄增长而增加。
oVEMPs是一种新的可靠、可重复的测试，用于评估前庭功能，可能还有耳石功能。
本研究展示了记录oVEMPs的最佳条件，并提供了个体差异和不对称性的基线值。oVEMPs可以在老年受试者中顺利测量。
