Hecker Dietmar J, Scherer Hans, Schönfeld Uwe, Jerono Laura, Koch Armand, Rink Anna-Katharina, Schulte-Goebel Lisa, Linxweiler Maximilian, Fousse Mathias, Bozzato Alessandro, Schick Bernhard
Department for Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66421 Homburg, Germany.
Charité University Medicine, 13353 Berlin, Germany.
J Clin Med. 2022 Nov 30;11(23):7124. doi: 10.3390/jcm11237124.
Bone-conducted (BC) VEMPs provide important tools for measuring otolith function. However, two major drawbacks of this method are encountered in clinical practice-small n10 amplitude and averaging technique. In this study, we present the results of a new VEMP setup measuring technique combined with a novel single-sweep analysis.
The study included BC oVEMP data from 92 participants for the evaluation of normative data using a novel analysis technique. For evaluating test-retest reliability, the intraclass correlation coefficient (ICC) was used.
We found significant n10 amplitude differences in single-sweep analyses after the first and second measurements. Thereby, mathematical analyses of the head movement did not show any differences in the first or second measurements. The normative n10 amplitude was 20.66 µV with an asymmetric ratio (AR) of 7%. The new value of late shift difference (LSD) was 0.01 ms. The test retest-reliability showed good to excellent ICC results in 9 out of 10 measurements.
Our results support a phenomenon in single-sweep analysis of the first stimuli independent of head movement and signal morphology. Furthermore, the values obtained with the new measurement method appear to be more sensitive and may allow an extended diagnostic range due to the new parameter LSD.
骨导（BC）前庭诱发肌源性电位（VEMP）为测量耳石功能提供了重要工具。然而，在临床实践中，该方法存在两个主要缺点——n10波幅小和平均技术。在本研究中，我们展示了一种结合新型单次扫描分析的新型VEMP设置测量技术的结果。
本研究纳入了92名参与者的BC oVEMP数据，使用一种新型分析技术评估标准数据。为评估重测信度，采用组内相关系数（ICC）。
我们发现在第一次和第二次测量后的单次扫描分析中，n10波幅存在显著差异。因此，头部运动的数学分析在第一次或第二次测量中未显示出任何差异。标准n10波幅为20.66µV，不对称率（AR）为7%。晚期偏移差异（LSD）的新值为0.01毫秒。在10次测量中有9次重测信度显示出良好至优秀的ICC结果。
我们的结果支持在单次扫描分析中首次刺激存在一种独立于头部运动和信号形态的现象。此外，由于新参数LSD，用新测量方法获得的值似乎更敏感，可能允许扩大诊断范围。
