老年男性双胞胎血浆同型半胱氨酸水平的遗传力估计

Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins.

作者信息

Reed T, Malinow M R, Christian J C, Upson B

机构信息

Department of Medical Genetics, Indiana University School of Medicine, Indianapolis.

出版信息

Clin Genet. 1991 Jun;39(6):425-8. doi: 10.1111/j.1399-0004.1991.tb03053.x.

DOI:10.1111/j.1399-0004.1991.tb03053.x

PMID:1863989

Abstract

Plasma homocyst(e)ine level was determined for 96 identical (MZ) and 92 fraternal (DZ) adult male twins aged 59-69. There was no difference in mean between MZ (10.31 nmol/ml) and DZ (10.36 nmol/ml) twins. The intraclass correlation coefficient of the log-transformed homocyst(e)ine level in 43 complete MZ and 39 complete DZ pairs was 0.55 and 0.19, respectively. The MZ correlation was significantly (p less than 0.05) greater than the DZ correlation, suggesting that the level of plasma homocyst(e)ine is genetically influenced.

摘要

对96对同卵（MZ）和92对异卵（DZ）成年男性双胞胎（年龄在59 - 69岁之间）测定了血浆同型半胱氨酸水平。MZ双胞胎（10.31纳摩尔/毫升）和DZ双胞胎（10.36纳摩尔/毫升）的平均值没有差异。43对完整的MZ双胞胎和39对完整的DZ双胞胎中，对数转换后的同型半胱氨酸水平的组内相关系数分别为0.55和0.19。MZ双胞胎的相关性显著（p小于0.05）高于DZ双胞胎的相关性，表明血浆同型半胱氨酸水平受遗传影响。