血浆同型半胱氨酸水平的人群变异与遗传学

Population variation and genetics of plasma homocyst(e)ine level.

作者信息

Berg K, Malinow M R, Kierulf P, Upson B

机构信息

Institute of Medical Genetics, University of Oslo, Norway.

出版信息

Clin Genet. 1992 Jun;41(6):315-21. doi: 10.1111/j.1399-0004.1992.tb03405.x.

DOI:10.1111/j.1399-0004.1992.tb03405.x

PMID:1623629

Abstract

A high level of plasma homocyst(e)ine (H(e)) has been reported to be an independent risk factor for coronary heart disease (CHD), at least in some populations. We have determined the H(e) concentration in the plasma of two series of Norwegians in order to establish a baseline for future analysis of people with CHD. The mean sex- and age-adjusted homocyst(e)ine level was 10.6 (range 4.84-29.88) in one series and 10.5 (range 3.76-40.57) in the other. The H(e) level appeared to be independent of other proven or potential risk factors or protective factors with respect to CHD. The intraclass correlation coefficient in monozygotic (MZ) twins is a (possibly inflated) estimate of heritability. We have examined two series of MZ twins. The intraclass correlation coefficient was significant in both series. In one series, the Pearson correlation coefficient was 0.53 and the Kendall correlation coefficient 0.38. In the other, the values were 0.56 and 0.46, respectively. We conclude that in the population examined, H(e) levels exhibit significant heritability.

摘要

据报道，至少在某些人群中，高血浆同型半胱氨酸（H（e））水平是冠心病（CHD）的独立危险因素。我们测定了两组挪威人的血浆H（e）浓度，以便为今后对冠心病患者的分析建立一个基线。一组经性别和年龄调整后的同型半胱氨酸平均水平为10.6（范围4.84 - 29.88），另一组为10.5（范围3.76 - 40.57）。就冠心病而言，H（e）水平似乎与其他已证实或潜在的危险因素或保护因素无关。同卵（MZ）双胞胎的组内相关系数是遗传度的一个（可能高估的）估计值。我们研究了两组MZ双胞胎。两组的组内相关系数均具有显著性。在一组中，Pearson相关系数为0.53，Kendall相关系数为0.38。在另一组中，相应的值分别为0.56和0.46。我们得出结论，在所研究的人群中，H（e）水平表现出显著的遗传度。