Pala Mauro, Ugolini Donatella, Ceppi Marcello, Rizzo Fabio, Maiorana Lucia, Bolognesi Claudia, Schilirò Tiziana, Gilli Giorgio, Bigatti Paola, Bono Roberto, Vecchio Daniela
Department of Epidemiology and Prevention, Unit of Environmental Chemistry and Carcinogenesis, National Cancer Research Institute, Genoa, Italy.
Cancer Detect Prev. 2008;32(2):121-6. doi: 10.1016/j.cdp.2008.05.003. Epub 2008 Jul 18.
The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect.
Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers.
Individual FA levels of exposure ranged from 4.9 microg/m(3) to 268.7 microg/m(3). Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences.
A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.
本研究旨在验证工作环境中的甲醛暴露与暴露生物标志物及效应生物标志物之间是否存在关联。
对某癌症研究所不同实验室的36名工人的甲醛（FA）暴露情况进行了检测，并在这些工人的外周血淋巴细胞中测量了暴露生物标志物，如甲醛人血清白蛋白结合物（FA-HSA），以及效应生物标志物，如染色体畸变（CA）、微核（MN）和姐妹染色单体交换（SCE）。
个体FA暴露水平在4.9微克/立方米至268.7微克/立方米之间。高FA暴露的受试者显示出暴露生物标志物FA-HSA显著增加，但效应生物标志物未显示出任何显著差异。
观察到职业性FA暴露与一种暴露生物标志物（FA-HSA）之间存在显著关联。所使用的效应标志物（CA、MN和SCE）未能表明存在遗传损伤。
