Department of Occupational Health, School of Health, Guilan University of Medical Sciences, Rasht, Iran.
Department of Management, West Tehran Branch-Islamic Azad University, Tehran, Iran.
Asian Pac J Cancer Prev. 2020 May 1;21(5):1303-1309. doi: 10.31557/APJCP.2020.21.5.1303.
Exposure to formaldehyde has adverse effects on health both acutely and over the long term (e.g., carcinogenicity). The substance is widely used in pathology and histology departments. This study focused on cancer risk of formaldehyde in pathology department of five hospitals in Rasht.
Sampling and determination of formaldehyde in pathology department were carried out based on the NIOSH method of 3500. The working condition and working environment were investigated and a semi quantitative risk assessment were used to health risk assessment of formaldehyde and The individual lifetime cancer probability, which is defined as the increase in the probability of developing cancer during continuous exposure to an air pollutant were used to assess health risks with formaldehyde.
The results showed that the exposure level of all subjects were higher than the Occupational Exposure Limit for 8 hours exposure time of formaldehyde. However, in the five occupational groups, the highest weekly exposure index was observed for the Lab Technicians (0.664 ppm) at Hospital no. 5, which could have been due to more daily working hours at this sampling site and a lack of adequate ventilation. The formaldehyde concentration was in the 0.0192 to 0.326 ppm ranges for five hospital pathology departments. The cancer risk ranged from 9.52×10-5 to 1.53×10-3, and it was greater than the WHO acceptable cancer risk level.
The results of the risk assessments can be used for managing the chemical exposure of allocated resources for defining control actions. This process plays an important role in reducing the level of exposure to formaldehyde in pathology departments.
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甲醛的暴露对健康既有急性影响,也有长期影响(例如致癌性)。该物质广泛应用于病理学和组织学部门。本研究集中于拉什特五家医院病理科的甲醛致癌风险。
根据 NIOSH 3500 方法对病理科的甲醛进行采样和测定。对工作条件和工作环境进行了调查,并使用半定量风险评估方法对甲醛的健康风险进行了评估,以及个体终生癌症概率,定义为在连续暴露于空气污染物期间癌症发生概率的增加,用于评估甲醛的健康风险。
结果表明,所有受试者的暴露水平均高于甲醛 8 小时暴露时间的职业暴露限值。然而,在五个职业群体中,第五医院的实验室技术员的最高每周暴露指数最高(0.664 ppm),这可能是由于该采样点的每日工作时间更长,通风不足。五个医院病理科的甲醛浓度范围在 0.0192 至 0.326 ppm 之间。癌症风险范围为 9.52×10-5 至 1.53×10-3,大于世界卫生组织可接受的癌症风险水平。
风险评估的结果可用于管理分配资源的化学暴露,以确定控制措施。这一过程在降低病理科甲醛暴露水平方面发挥着重要作用。