不同聚阴离子与补体第一成分（C1、C1）、第二成分（C2）和第四成分（C4）的相互作用方式。IV. 聚阴离子对血清中C1的激活作用。
Mode of interaction of different polyanions with the first (C1,C1) the second (C2) and the fourth (C4) component of complement. IV. Activation of C1 in serum by polyanions.
作者信息
Loos M, Bitter-Suermann D
出版信息
Immunology. 1976 Dec;31(6):931-4.
Abstract
Treatment of serum with dextransulphate polyvinylsulphate or polyanetholsulphonate resulted in a dose-dependent activation of C1 and C3; this was found for normal serum as well as for C4-deficient guinea-pig serum. Activation of C1 and C3 occurred at the same concentration of polyanions. The consumption of C3 in C4 deficient serum and the requirement of factor D of the alternative pathway indicate that C3 is activated via the alternative pathway.
摘要
用硫酸葡聚糖、聚乙烯硫酸酯或聚茴香脑磺酸钠处理血清会导致C1和C3呈剂量依赖性激活；在正常血清以及C4缺陷豚鼠血清中均发现了这种情况。C1和C3在相同浓度的聚阴离子下被激活。C4缺陷血清中C3的消耗以及替代途径中D因子的需求表明C3是通过替代途径被激活的。
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