Lutey Barbara A, Lefrak Stephen S, Woods Jason C, Tanoli Tariq, Quirk James D, Bashir Adil, Yablonskiy Dmitriy A, Conradi Mark S, Bartel Seth T, Pilgram Thomas K, Cooper Joel D, Gierada David S
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA.
Radiology. 2008 Aug;248(2):655-61. doi: 10.1148/radiol.2482071838.
To evaluate the safety of hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging.
Local institutional review board approval and informed consent were obtained. Physiologic monitoring data were obtained before, during, and after hyperpolarized (3)He MR imaging in 100 consecutive subjects (57 men, 43 women; mean age, 52 years +/- 14 [standard deviation]). The subjects inhaled 1-3 L of a gas mixture containing 300-500 mL (3)He and 0-2700 mL N(2) and held their breath for up to 15 seconds during MR imaging. Heart rate and rhythm and oxygen saturation of hemoglobin as measured by pulse oximetry (Spo(2)) were monitored continuously throughout each study. The effects of (3)He MR imaging on vital signs and Spo(2) and the relationship between pulmonary function, number of doses, and clinical classification (healthy volunteers, patients with asthma, heavy smokers, patients undergoing lung volume reduction surgery for severe emphysema, and patients with lung cancer) and the lowest observed Spo(2) were assessed. Any subjective symptoms were noted.
Except for a small postimaging decrease in mean heart rate (from 78 beats per minute +/- 13 to 73 beats per minute +/- 11, P < .001), there was no effect on vital signs. A mean transient decrease in Spo(2) of 4% +/- 3 was observed during the first minute after gas inhalation (P < .001) in 77 subjects who inhaled a dose of 1 L for 10 seconds or less, reaching a nadir of less than 90% at least once in 20 subjects and of less than 85% in four subjects. There was no correlation between the lowest Spo(2) and pulmonary function parameters other than baseline Spo(2) (r = 0.36, P = .001). The lowest mean Spo(2) varied by 1% between the first and second and second and third doses (P < .001) and was unrelated to clinical classification (P = .40). Minor subjective symptoms were noted by 10 subjects. No serious adverse events occurred.
Hyperpolarized (3)He MR imaging can be safely performed in healthy subjects, heavy smokers, and those with severe obstructive airflow limitation, although unpredictable transient desaturation suggests that potential subjects should be carefully screened for comorbidities.
评估超极化氦3（³He）磁共振成像（MRI）的安全性。
获得当地机构审查委员会批准并取得知情同意。在100名连续受试者（57名男性，43名女性；平均年龄52岁±14[标准差]）进行超极化³He MRI成像之前、期间和之后获取生理监测数据。受试者吸入1 - 3 L含有300 - 500 mL³He和0 - 2700 mL N₂的混合气体，并在MRI成像期间屏气长达15秒。在每项研究过程中持续监测心率、心律以及通过脉搏血氧饱和度仪测量的血红蛋白氧饱和度（Spo₂）。评估³He MRI成像对生命体征和Spo₂的影响，以及肺功能、剂量数和临床分类（健康志愿者、哮喘患者、重度吸烟者、因严重肺气肿接受肺减容手术的患者以及肺癌患者）与观察到的最低Spo₂之间的关系。记录任何主观症状。
除成像后平均心率有小幅下降（从每分钟78次±13降至每分钟73次±11，P <.001）外，对生命体征无影响。在77名吸入1 L剂量持续10秒或更短时间的受试者中，吸入气体后第一分钟内观察到Spo₂平均短暂下降4%±3（P <.001），20名受试者中至少有一次最低值低于90%，4名受试者低于85%。除基线Spo₂外，最低Spo₂与肺功能参数之间无相关性（r = 0.36，P =.001）。第一剂和第二剂以及第二剂和第三剂之间最低平均Spo₂相差1%（P <.001），且与临床分类无关（P =.40）。10名受试者记录到轻微主观症状。未发生严重不良事件。
超极化³He MRI成像可在健康受试者、重度吸烟者以及患有严重阻塞性气流受限的患者中安全进行，尽管不可预测的短暂去饱和提示应对潜在受试者仔细筛查合并症。
