促肾上腺皮质激素。48. （15, 16 - D - 赖氨酸，17, 18 - D - 精氨酸）-促肾上腺皮质激素 -（1 - 19）及一种与促肾上腺皮质激素氨基末端十八肽相关的全D - 反向肽的合成与生物活性。
Adrenocorticotropin. 48. Synthesis and biological activity of (15, 16-D-lysine, 17, 18-D-arginine)-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin.
作者信息
Blake J, Li C H
出版信息
Int J Pept Protein Res. 1976;8(6):589-95. doi: 10.1111/j.1399-3011.1976.tb02539.x.
Abstract
The peptide [15, 16-D-lysine, 17, 18-D-arginine]-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin have been synthesized by the solid-phase method. The nonadecapeptide was shown to possess 10-15% of the steroidogenic activity and 3% of the lipolytic activity of adrenocorticotropin-(1-19). The all-D-retropeptide showed no activity and exhibited no inhibitory activity in steroidogenesis and lipolysis.
摘要
已通过固相法合成了肽[15,16-D-赖氨酸，17,18-D-精氨酸]-促肾上腺皮质激素-(1-19)以及一种与促肾上腺皮质激素氨基末端十八肽相关的全D型逆肽。该十九肽显示出具有促肾上腺皮质激素-(1-19)的10-15%的类固醇生成活性和3%的脂解活性。全D型逆肽在类固醇生成和脂解中无活性且无抑制活性。
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