Blake J, Rao A J, Li C H
Int J Pept Protein Res. 1979 Mar;13(3):346-52. doi: 10.1111/j.1399-3011.1979.tb01891.x.
Three analogs of the amino terminal nonadecopeptide of adrenocorticotropin which incorporate cystine cystine bridges between positions (5, 10), (3, 10), or (2, 10) have been synthesized. All of the peptide analogs showed reduced biological activity; however, the peptide with the 5, 10 cystine bridge was shown to possess significantly higher lipolytic activity in rat fat cells than the peptides with a 3, 10 or 2, 10 cystine bridge.
已合成促肾上腺皮质激素氨基末端十九肽的三种类似物，它们在（5,10）、（3,10）或（2,10）位之间形成了胱氨酸 - 胱氨酸桥。所有肽类似物的生物活性均降低；然而，具有5,10胱氨酸桥的肽在大鼠脂肪细胞中显示出比具有3,10或2,10胱氨酸桥的肽显著更高的脂解活性。
