成年阿拉伯狒狒（Papio hamadryas）的骨质减少和骨质疏松
Osteopenia and osteoporosis in adult baboons (Papio hamadryas).
作者信息
Havill L M, Levine S M, Newman D E, Mahaney M C
机构信息
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
出版信息
J Med Primatol. 2008 Jun;37(3):146-53. doi: 10.1111/j.1600-0684.2007.00270.x.
BACKGROUND
Little is known about the degree to which baboons, an important animal model in skeletal research, spontaneously experience age-related osteopenia and osteoporosis.
METHODS
We measured bone mineral density (BMD) in 667 baboons, assigned T-scores to older animals based on sex-specific young adult reference groups, and compared reproductive history in older females with low BMD to those with normal BMD.
RESULTS
Approximately 25% of older baboon females were osteopenic. No females or males were osteoporotic. Neither parity nor interbirth interval spine clearly distinguished low vs. normal BMD groups. Intersite correspondence in low BMD was highest between sites in the same region rather than sites of the same bone type.
CONCLUSION
As with humans, osteopenia is common among older females. The absence of osteoporotic animals may be due to colony maintenance resulting in truncation of the aged population and selection for healthier animals in the oldest ranges.
背景
在骨骼研究中，狒狒作为一种重要的动物模型，其自发出现与年龄相关的骨质减少和骨质疏松的程度鲜为人知。
方法
我们测量了667只狒狒的骨密度（BMD），根据特定性别的年轻成年参考组为老年动物分配T值，并比较了低骨密度老年雌性与正常骨密度老年雌性的生殖史。
结果
约25%的老年雌性狒狒患有骨质减少。没有雌性或雄性患有骨质疏松症。产次和脊柱生育间隔均未明确区分低骨密度组与正常骨密度组。同一区域内各部位之间低骨密度的部位对应性最高，而非同一骨类型的部位之间。
结论
与人类一样，骨质减少在老年雌性中很常见。没有骨质疏松动物可能是由于群体维持导致老年种群截断，以及在最老年龄段选择了更健康的动物。
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