Ballus C, Gasto C
Servicio de Psiquiatria Hospital Clinico y Provincial de Barcelona, Facultad de Medicina, Universidad de Barcelona.
Encephale. 1991 May-Jun;17 Spec No 1:133-7.
The second generation of antidepressants have been developed with the goal to reduce cardio-toxic effects and to further a more specific action on neurotransmitter systems. However some standardized actual parameters, clinical, biological and pharmacological may be accepted as reasonable elements in evaluating the therapeutic effects. Among them we will distinguish the diagnostic instruments which define categories of affective disorders; rating scales to assess gravity, the type of clinical test, duration of the test and finally those biological variables which should be an integral part of the evaluation of new antidepressants.
第二代抗抑郁药的研发目标是降低心脏毒性作用，并进一步对神经递质系统产生更具特异性的作用。然而，一些标准化的实际参数，包括临床、生物学和药理学参数，可被视为评估治疗效果的合理要素。其中，我们将区分定义情感障碍类别的诊断工具；评估严重程度的评定量表、临床测试类型、测试持续时间，以及最终那些应成为新型抗抑郁药评估不可或缺一部分的生物学变量。
