Panteleeva G P, Beliaev B S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(10):115-9.
A comparative clinical analysis was made of the therapeutic efficacy of 13 atypical antidepressants (of the second generation and novel ones) and 5 typical (tricyclic) antidepressants in 1107 patients with depressions of varying nosology, syndromal structure and gravity. The data on psychotropic activity of atypical antidepressants and preferable indications for their administration are provided. The correlations between thymoleptic, anxiolytic and activating influences seen in the spectrum of their psychotropic action are discussed. Recommendations are given for the treatment with these agents of relatively mild depressions of the neurotic and psychopathic types in slow-progressive and border-line mental diseases. It is assumed that the second generation antidepressants occupy an intermediate position between antidepressants, tranquilizers and psychostimulants in the current systematics of psychotropic agents.
对1107例患有不同疾病分类、综合征结构和严重程度抑郁症的患者，进行了13种非典型抗抑郁药（第二代及新型）与5种典型（三环类）抗抑郁药治疗效果的比较临床分析。提供了非典型抗抑郁药的精神活性数据及其给药的优选适应症。讨论了在其精神活性作用谱中观察到的抗抑郁、抗焦虑和激活作用之间的相关性。给出了使用这些药物治疗缓慢进展性和边缘性精神疾病中相对轻度的神经症和精神opathic型抑郁症的建议。假定在目前的精神药物分类系统中，第二代抗抑郁药在抗抑郁药、镇静剂和精神兴奋剂之间占据中间位置。
