[Activity of the glutathione system of antioxidant defense in rats under the action of L-glutamic acid].

The data on the effects of glutamic acid (L-Glu), which is one of three amino acid - precursors ofglutathione on animals organism is quite controversial because research in this area remain relevant. The aim of our research was to find out what impact the additional introduction of L-Glu on the activity glutathione system of antioxidant defence and the content of lipid peroxidation products in various organs and tissues of rats. The effect of additional (285 and 715 mg/kg, respectively) introduction to the diet of L-Glu on the activity of antioxidant enzymes and intensity of peroxidation processes in various tissues of rats was studied. It is shown that in the liver, spleen and kidneys of rats which received additional 715 mg/kg of L-Glu content of reduced glutathione and glutathione peroxidase activity increased. A decrease of the content of lipid hydroperoxides and TBA-active products in tissues of animals which received additional 285 and 715 mg/kg of L-Glu into the diet was found. We have also found that the enrichment of rat's diet by L-Glu during 30 days resulted in a change of glutathione part of antioxidant system and intensity of lipid peroxidation. More intensive changes in these indices were observed in animals which received additional 715 mg/kg of L-Glu into the diet.