Munaron Luca, Tomatis Cristiana, Fiorio Pla Alessandra
Department of Animal and Human Biology, University of Turin, Italy.
Technol Cancer Res Treat. 2008 Aug;7(4):335-9. doi: 10.1177/153303460800700408.
Endothelial cell biochemistry and responsiveness to a wide variety of external stimula is regulated by intracellular calcium concentration. During the last twenty years, electrophysiology and functional imaging based on the use of fluorescent probes provided several informations about the dynamics and role of calcium at the single cell level: highly diverse extracellular agonists, such as proangiogenic growth factors and vasoactive compounds, trigger increases in intracellular calcium and specific informations are transduced for proliferation, differentiation, death, movement in physiological and pathological conditions. Obviously, the investigation at multicellular and tissutal levels is much more complex. In this review we discuss the potential specific roles of calcium signaling in tumor angiogenesis progression trying to address two key questions: (i) how can this ion play specific roles in the angiogenesis regulation; and (ii) could it be used as a target to interfere with or prevent tumor vascularization?
内皮细胞生物化学以及对多种外部刺激的反应性受细胞内钙浓度调节。在过去二十年中，基于荧光探针的电生理学和功能成像提供了关于单细胞水平钙的动态变化及其作用的若干信息：多种细胞外激动剂，如促血管生成生长因子和血管活性化合物，可触发细胞内钙增加，并在生理和病理条件下转导有关增殖、分化、死亡、迁移的特定信息。显然，在多细胞和组织水平上的研究要复杂得多。在本综述中，我们讨论钙信号在肿瘤血管生成进展中的潜在特定作用，试图解决两个关键问题：（i）这种离子如何在血管生成调节中发挥特定作用；（ii）它能否用作干扰或预防肿瘤血管化的靶点？
