Metcalf M F, McNeill J I, Kaufman H E
Invest Ophthalmol. 1976 Dec;15(12):979-85.
The development of experimental disciform edema and necrotizing keratitis in the corneas or rabbits following intrastromal inoculation with the RE strain of herpes simplex virus is described. Following an initial episode of conjunctivitis and epithelial keratitis, a mild, centrally localized, stromal edema developed on the fifth day. Stromal edema, opcification, and neovascularization of the cornea reached maximum severity on the seventh to twenty-second day, and began to fade in most eyes thereafter. On the twenty-ninth day most corneas have attained a resolved state characterized by subepithelial granular opacities. Several eyes were observed which developed central necrotizing keratitis. Marked similarities between the animal model and human herpetic stromal keratitis were apparent. Histological observations show that early necrotizing keratitis in the rabbit is characterized by an infiltration of plasma cells and lymphocytes in the limbus, with polymorphonuclear leukocytes, lymphocytes, and macrophages in the central cornea.
描述了在家兔角膜基质内接种单纯疱疹病毒RE株后实验性盘状水肿和坏死性角膜炎的发展情况。在最初的结膜炎和上皮性角膜炎发作后，第5天出现轻度的、中央局限性的基质水肿。角膜的基质水肿、混浊和新生血管在第7至22天达到最严重程度，此后大多数眼睛开始消退。在第29天，大多数角膜达到了以角膜上皮下颗粒状混浊为特征的消退状态。观察到几只眼睛发展为中央坏死性角膜炎。动物模型与人类疱疹性基质角膜炎之间存在明显的相似之处。组织学观察表明，兔早期坏死性角膜炎的特征是角膜缘有浆细胞和淋巴细胞浸润，中央角膜有多形核白细胞、淋巴细胞和巨噬细胞浸润。
