Mukherji Sutapa
Department of Physics, Indian Institute of Technology, Kanpur 208016, India.
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 May;77(5 Pt 1):051916. doi: 10.1103/PhysRevE.77.051916. Epub 2008 May 19.
Cytoplasmic dyneins transport cellular organelles by moving on a microtubule filament. It has been found recently that depending on the applied force and the concentration of the adenosine triphosphate molecules, dynein's step size varies. Based on these studies, we propose a simple model for dynein's unidirectional motion taking into account the variations in its step size. We study how the average velocity and the relative dispersion in the displacement vary with the applied load. The model is amenable to further extensions by inclusion of details associated with the structure and the processivity of the molecule.
胞质动力蛋白通过在微管丝上移动来运输细胞细胞器。最近发现，根据所施加的力和三磷酸腺苷分子的浓度，动力蛋白的步长会发生变化。基于这些研究，我们考虑到步长的变化，提出了一个关于动力蛋白单向运动的简单模型。我们研究了平均速度和位移的相对离散度如何随所施加的负载而变化。该模型可以通过纳入与分子结构和持续性相关的细节进行进一步扩展。
