一种源自单纯疱疹病毒ANG株的异常缺陷基因型。
An unusual defective genotype derived from herpes simplex virus strain ANG.
作者信息
Schröder C H, Stegmann B, Lauppe H F, Kaerner H C
出版信息
Intervirology. 1975;6(4-5):270-84. doi: 10.1159/000149481.
A defective genotype of herpes simplex virus strain Angelotti (HSV ANG) accumulates in the course of controlled serial high MOI virus passages representing 50-60% of the total number of mature virions in the seventh of these passages. Defective HSV ANG significantly differs from other defective HSV genotypes described so far: the DNA of the defective particles has the same buoyant density as nondefective DNA. In contrast to non-defective HSV ANG DNA, it is not attacked by the restriction endonucleases Eco R I, Hpa I and Hind III. Defective virions strongly suppress the formation of progeny virus. They do not interfere, however, with the synthesis of HSV-specified thymidine (TdR) kinase.
单纯疱疹病毒安杰洛蒂株（HSV ANG）的一种缺陷基因型在连续高感染复数（MOI）的病毒传代过程中积累，在这些传代的第七代中占成熟病毒粒子总数的50 - 60%。缺陷型HSV ANG与迄今描述的其他缺陷型HSV基因型有显著差异：缺陷粒子的DNA与非缺陷DNA具有相同的浮力密度。与非缺陷型HSV ANG DNA不同，它不受限制性内切酶Eco R I、Hpa I和Hind III的切割。缺陷病毒粒子强烈抑制子代病毒的形成。然而，它们并不干扰HSV特异性胸苷（TdR）激酶的合成。
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