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Chimerism and liver transplant tolerance.嵌合现象与肝移植耐受
J Hepatol. 2008 Sep;49(3):478-80. doi: 10.1016/j.jhep.2008.06.021. Epub 2008 Jul 11.
2
Donor programmed cell death 1 ligand 1 is required for organ transplant tolerance in major histocompatibility complex-mismatched mixed chimeras although programmed cell death 1 ligand 1 and major histocompatibility complex class II are not required for inducing chimerism.供者程序性细胞死亡受体 1 配体 1 对于主要组织相容性复合物错配的混合嵌合体中的器官移植耐受是必需的，尽管程序性细胞死亡受体 1 配体 1 和主要组织相容性复合物 II 对于诱导嵌合并不必需。
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3
Living donor liver transplant with clinical tolerance, laboratory evidence of chimerism, and spontaneous clearance of HBV.活体供肝移植伴临床耐受、嵌合体的实验室证据及乙肝病毒的自发清除。
Liver Transpl. 2004 Nov;10(11):1432-5. doi: 10.1002/lt.20278.
4
Chimerism but not neonatal antigen exposure induces transplant tolerance.嵌合体而非新生儿期抗原暴露诱导移植耐受。
Scand J Immunol. 2012 Aug;76(2):108-12. doi: 10.1111/j.1365-3083.2012.02711.x.
5
Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion.通过移植后供体淋巴细胞输注增加供体嵌合状态并诱导对胰岛同种异体移植物的耐受。
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Transient-mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates.非清髓性预处理诱导的短暂混合嵌合体并不诱导非人灵长类肝脏移植物耐受。
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7
Complex chimerism: pregnancy after solid organ transplantation.复杂嵌合现象：实体器官移植后的妊娠
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8
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance.同种异体反应性调节性T细胞可实现混合嵌合体的生成及移植耐受。
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[Transplant tolerance through mixed chimerism].通过混合嵌合体实现移植耐受
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Chimerism, Transplant Tolerance, and Beyond.嵌合体、移植耐受及其他。
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引用本文的文献

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Comparison of bone microstructures via high-resolution peripheral quantitative computed tomography in patients with different stages of chronic kidney disease before and after starting hemodialysis.比较不同阶段慢性肾脏病患者开始血液透析前后的高分辨率外周定量计算机断层扫描的骨微观结构。
Ren Fail. 2022 Dec;44(1):381-391. doi: 10.1080/0886022X.2022.2043375.
2
Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation.肝移植中 Treg 诱导免疫耐受的临床与基础研究进展。
Front Immunol. 2021 May 20;12:535012. doi: 10.3389/fimmu.2021.535012. eCollection 2021.
3
Immune monitoring as prerequisite for transplantation tolerance trials.免疫监测作为移植耐受试验的前提条件。
Clin Exp Immunol. 2017 Aug;189(2):158-170. doi: 10.1111/cei.12988. Epub 2017 Jun 23.
4
Immune monitoring post liver transplant.肝移植后的免疫监测
World J Transplant. 2014 Mar 24;4(1):30-9. doi: 10.5500/wjt.v4.i1.30.

本文引用的文献

1
Immune tolerance: mechanisms and application in clinical transplantation.免疫耐受：机制及其在临床移植中的应用
J Intern Med. 2007 Sep;262(3):288-310. doi: 10.1111/j.1365-2796.2007.01855.x.
2
The liver: a special case in transplantation tolerance.肝脏：移植耐受中的特殊情况。
Semin Liver Dis. 2007 May;27(2):194-213. doi: 10.1055/s-2007-979471.
3
Operational tolerance in clinical liver transplantation: emerging developments.临床肝移植中的手术耐受性：新进展
Transpl Immunol. 2007 Feb;17(2):108-13. doi: 10.1016/j.trim.2006.09.021. Epub 2006 Sep 27.
4
Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation.小儿活体肝移植术后手术耐受的临床、免疫学及病理学方面
Transpl Immunol. 2007 Feb;17(2):94-7. doi: 10.1016/j.trim.2006.10.004. Epub 2006 Nov 10.
5
Liver transplantation in children.儿童肝移植
J Hepatol. 2007 Feb;46(2):340-8. doi: 10.1016/j.jhep.2006.11.006. Epub 2006 Dec 1.
6
The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation.
Am J Transplant. 2005 Mar;5(3):608-13. doi: 10.1111/j.1600-6143.2004.00743.x.
7
Th2 cytokine profile in infants predisposes to improved graft acceptance after liver transplantation.婴儿的Th2细胞因子谱有利于肝移植后移植肝的接受。
Transplantation. 2001 Sep 15;72(5):929-34. doi: 10.1097/00007890-200109150-00031.
8
Viral subversion of the immune system.病毒对免疫系统的颠覆。
Annu Rev Immunol. 2000;18:861-926. doi: 10.1146/annurev.immunol.18.1.861.
9
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.免疫抑制药物所允许的供体细胞嵌合现象：器官移植的新视角。
Immunol Today. 1993 Jun;14(6):326-32. doi: 10.1016/0167-5699(93)90054-o.
10
Early tolerance in pediatric liver allograft recipients.小儿肝移植受者的早期耐受
J Pediatr Surg. 1994 Jun;29(6):754-6. doi: 10.1016/0022-3468(94)90362-x.

嵌合现象与肝移植耐受

Chimerism and liver transplant tolerance.

作者信息

Mineo Davide, Ricordi Camillo

机构信息

Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 N.W. 10 Avenue, Miami, FL 33136, USA.

出版信息

J Hepatol. 2008 Sep;49(3):478-80. doi: 10.1016/j.jhep.2008.06.021. Epub 2008 Jul 11.

DOI:10.1016/j.jhep.2008.06.021
PMID:18644653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2580069/
Abstract

Chimerism and tolerance in a recipient of a deceased-donor liver transplant. Alexander SI, Smith N, Hu M, Verran D, Shun A, Dorney S, Smith A, Webster B, Shaw PJ, Lammi A, Stormon MO. Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.

摘要

一位已故供体肝脏移植受者的嵌合现象与免疫耐受。亚历山大·S·I、史密斯·N、胡·M、韦兰·D、顺·A、多尼·S、史密斯·A、韦伯斯特·B、肖·P·J、拉米·A、斯托蒙·M·O。一名9岁女孩出现了完全造血嵌合现象，并对来自已故男性供体的肝脏移植物产生了免疫耐受，移植17个月后未出现移植物抗宿主病迹象。在免疫耐受之前有一段严重溶血期，这反映了部分嵌合现象，且对标准治疗无效。在逐渐停用所有免疫抑制治疗后，溶血现象消失。