嵌合现象与肝移植耐受
Chimerism and liver transplant tolerance.
作者信息
Mineo Davide, Ricordi Camillo
机构信息
Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 N.W. 10 Avenue, Miami, FL 33136, USA.
出版信息
J Hepatol. 2008 Sep;49(3):478-80. doi: 10.1016/j.jhep.2008.06.021. Epub 2008 Jul 11.
Abstract
Chimerism and tolerance in a recipient of a deceased-donor liver transplant. Alexander SI, Smith N, Hu M, Verran D, Shun A, Dorney S, Smith A, Webster B, Shaw PJ, Lammi A, Stormon MO. Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9-year-old girl, with no evidence of graft-versus-host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.
摘要
一位已故供体肝脏移植受者的嵌合现象与免疫耐受。亚历山大·S·I、史密斯·N、胡·M、韦兰·D、顺·A、多尼·S、史密斯·A、韦伯斯特·B、肖·P·J、拉米·A、斯托蒙·M·O。一名9岁女孩出现了完全造血嵌合现象，并对来自已故男性供体的肝脏移植物产生了免疫耐受，移植17个月后未出现移植物抗宿主病迹象。在免疫耐受之前有一段严重溶血期，这反映了部分嵌合现象，且对标准治疗无效。在逐渐停用所有免疫抑制治疗后，溶血现象消失。
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本文引用的文献
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