• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

小儿肝移植受者的早期耐受

Early tolerance in pediatric liver allograft recipients.

作者信息

Tzakis A G, Reyes J, Zeevi A, Ramos H, Nour B, Reinsmoen N, Todo S, Starzl T E

机构信息

Transplantation Institute, University of Pittsburgh, PA 15213.

出版信息

J Pediatr Surg. 1994 Jun;29(6):754-6. doi: 10.1016/0022-3468(94)90362-x.

DOI:10.1016/0022-3468(94)90362-x
PMID:8078013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2963428/
Abstract

The authors report on six pediatric liver transplant recipients for whom allograft tolerance occurred shortly after transplantation (ie, less than 1.5 years). All the patients had associated life-threatening viral complications. They are currently immunocompetent. The tolerant state may be related to the development of a TH2 cytokine pattern.

摘要

作者报告了6例小儿肝移植受者,他们在移植后不久(即不到1.5年)就出现了移植物耐受。所有患者都伴有危及生命的病毒并发症。他们目前具有免疫能力。耐受状态可能与TH2细胞因子模式的形成有关。

相似文献

1
Early tolerance in pediatric liver allograft recipients.小儿肝移植受者的早期耐受
J Pediatr Surg. 1994 Jun;29(6):754-6. doi: 10.1016/0022-3468(94)90362-x.
2
Comparison of T cell responses in patients with a long-term surviving renal allograft versus a long-term surviving liver allograft. It's a different world.长期存活的肾移植受者与长期存活的肝移植受者的T细胞反应比较。这是一个不同的情况。
Transplantation. 1996 May 15;61(9):1392-7. doi: 10.1097/00007890-199605150-00019.
3
[Development of immune tolerance in liver transplantation].[肝移植中免疫耐受的发展]
Gastroenterol Hepatol. 2011 Mar;34(3):155-69. doi: 10.1016/j.gastrohep.2010.11.007. Epub 2011 Mar 3.
4
Pre- and post-transplant monitoring of granzyme B enzyme-linked immunosorbent spot assay in pediatric liver recipients.儿童肝移植受者移植前后颗粒酶B酶联免疫斑点试验的监测
Transpl Immunol. 2008 Jul;19(3-4):215-9. doi: 10.1016/j.trim.2008.06.001. Epub 2008 Jul 2.
5
Establishment and validation of a predictive model of immune tolerance after pediatric liver transplantation: a multicenter cohort study.小儿肝移植后免疫耐受预测模型的建立与验证:一项多中心队列研究
Int J Surg. 2024 Sep 1;110(9):5615-5626. doi: 10.1097/JS9.0000000000001671.
6
Human liver allograft acceptance and the "tolerance assay": in vitro anti-donor T cell assays show hyporeactivity to donor cells, but unlike DTH, fail to detect linked suppression.人肝同种异体移植的接受与“耐受检测”:体外抗供体T细胞检测显示对供体细胞反应低下,但与迟发型超敏反应不同,未能检测到连锁抑制。
Transplantation. 2001 Aug 27;72(4):571-80. doi: 10.1097/00007890-200108270-00004.
7
Systemic and local immune responses in allograft tolerance following swine liver transplantation.猪肝移植后同种异体移植耐受中的全身和局部免疫反应。
Transplant Proc. 1991 Feb;23(1 Pt 1):561-4.
8
Split tolerance induced by orthotopic liver transplantation in mice.小鼠原位肝移植诱导的分裂耐受
Transplantation. 1994 Jul 15;58(1):1-8. doi: 10.1097/00007890-199407000-00001.
9
Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.
Transplantation. 2001 Oct 27;72(8 Suppl):S13-22.
10
Relationship between TH1/TH2 cytokines and immune tolerance in liver transplantation in rats.大鼠肝移植中TH1/TH2细胞因子与免疫耐受的关系
Transplant Proc. 2008 Oct;40(8):2691-5. doi: 10.1016/j.transproceed.2008.08.014.

引用本文的文献

1
Establishment and validation of a predictive model of immune tolerance after pediatric liver transplantation: a multicenter cohort study.小儿肝移植后免疫耐受预测模型的建立与验证:一项多中心队列研究
Int J Surg. 2024 Sep 1;110(9):5615-5626. doi: 10.1097/JS9.0000000000001671.
2
Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance?肝移植的新进展:我们在追求移植耐受的道路上走了多远?
Eur J Immunol. 2021 Oct;51(10):2373-2386. doi: 10.1002/eji.202048875. Epub 2021 Sep 4.
3
Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment.供者特异性调节性 T 细胞介导的免疫耐受在短期抗 CD154mAb 单药治疗的肝内同种异体胰岛移植模型中的作用。
Cell Transplant. 2020 Jan-Dec;29:963689720913876. doi: 10.1177/0963689720913876.
4
BIOMARKERS OF OPERATIONAL TOLERANCE IN SOLID ORGAN TRANSPLANTATION.实体器官移植中手术耐受性的生物标志物
Expert Opin Med Diagn. 2012 Jul;6(4):281-293. doi: 10.1517/17530059.2012.680019.
5
HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance.单核细胞样树突状细胞上 HLA-G 水平与肝移植耐受中的调节性 T 细胞 Foxp3 表达相关。
Transplantation. 2011 May 27;91(10):1132-40. doi: 10.1097/TP.0b013e31821414c9.
6
Chimerism and liver transplant tolerance.嵌合现象与肝移植耐受
J Hepatol. 2008 Sep;49(3):478-80. doi: 10.1016/j.jhep.2008.06.021. Epub 2008 Jul 11.
7
Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.同种异体移植耐受诱导中自然杀伤T(NKT)细胞的需求。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2577-81. doi: 10.1073/pnas.041608298. Epub 2001 Feb 20.

本文引用的文献

1
Homotransplantation of multiple visceral organs.多个内脏器官的同种移植
Am J Surg. 1962 Feb;103:219-29. doi: 10.1016/0002-9610(62)90491-9.
2
Cytokine mRNA profiles in Epstein-Barr virus-associated post-transplant lymphoproliferative disorders.爱泼斯坦-巴尔病毒相关移植后淋巴组织增生性疾病中的细胞因子mRNA谱
Clin Transplant. 1999 Feb;13(1 Pt 1):39-44. doi: 10.1034/j.1399-0012.1999.t01-2-130106.x.
3
Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.全器官移植后的细胞迁移与嵌合现象:移植物接受的基础
Hepatology. 1993 Jun;17(6):1127-52.
4
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.免疫抑制药物所允许的供体细胞嵌合现象:器官移植的新视角。
Immunol Today. 1993 Jun;14(6):326-32. doi: 10.1016/0167-5699(93)90054-o.
5
Frequent achievement of a drug-free state after orthotopic liver transplantation.原位肝移植后频繁实现无药状态。
Transplant Proc. 1993 Dec;25(6):3315-9.
6
Cytokine regulation of T-cell function: potential for therapeutic intervention.细胞因子对T细胞功能的调节:治疗干预的潜力。
Immunol Today. 1993 Jun;14(6):270-4. doi: 10.1016/0167-5699(93)90044-L.
7
Liver and kidney transplantation in children receiving cyclosporin A and steroids.接受环孢素A和类固醇治疗的儿童的肝移植和肾移植
J Pediatr. 1982 May;100(5):681-6. doi: 10.1016/s0022-3476(82)80564-7.
8
Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy.在环孢素-类固醇治疗下发生的淋巴瘤和淋巴增殖性病变的可逆性。
Lancet. 1984 Mar 17;1(8377):583-7. doi: 10.1016/s0140-6736(84)90994-2.
9
Induction of immunological tolerance by porcine liver allografts.猪肝同种异体移植诱导免疫耐受
Nature. 1969 Aug 2;223(5205):472-6. doi: 10.1038/223472a0.
10
Acquired donor-specific hyporesponsiveness in long-term kidney allograft recipients.
Transplant Proc. 1991 Feb;23(1 Pt 1):141-2.