Uzlova Svetlana G, Guria Konstantin G, Guria Georgy Th
National Research Centre for Haematology, 125167 Moscow, Russia.
Philos Trans A Math Phys Eng Sci. 2008 Oct 13;366(1880):3649-61. doi: 10.1098/rsta.2008.0109.
The blood coagulation system (BCS) is a complex biological system playing a principal role in the maintenance of haemostasis. Insufficient activity of the BCS may lead to bleeding and blood loss (e.g. in the case of haemophilia). On the other hand, excessive activity may cause intravascular blood coagulation, thromboses and embolization. Most of the methods currently used for BCS monitoring suffer from the major disadvantage of being invasive. The purpose of the present work is to demonstrate the feasibility of using ultrasonic methods for non-invasive registration of the early stages of blood coagulation processes in intensive flows. With this purpose, a special experimental set-up was designed, facilitating the simultaneous detection of optical and acoustic signals during the clotting process. It was shown that (i) as microemboli appear in the flow during the early stage of blood coagulation, the intensity of the Doppler signal increases twofold, and (ii) microemboli formation in the early stages of blood clotting always reveals itself through an acoustic contrast. Both of these effects are well defined, so we hope that they may be used for non-invasive BCS monitoring in clinical practice.
血液凝固系统（BCS）是一个复杂的生物系统，在维持止血过程中起主要作用。BCS活性不足可能导致出血和失血（例如在血友病的情况下）。另一方面，活性过高可能导致血管内血液凝固、血栓形成和栓塞。目前用于BCS监测的大多数方法都存在侵入性这一主要缺点。本研究的目的是证明使用超声方法对强血流中血液凝固过程早期阶段进行无创记录的可行性。为此，设计了一种特殊的实验装置，便于在凝血过程中同时检测光学和声学信号。结果表明：（i）在血液凝固早期，随着微栓子出现在血流中，多普勒信号强度增加两倍；（ii）血液凝固早期微栓子的形成总是通过声学造影表现出来。这两种效应都很明确，因此我们希望它们可用于临床实践中的无创BCS监测。
