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随机分配接受卡马西平、苯妥英钠和丙戊酸钠治疗的癫痫新发病例中的认知障碍。

Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate.

作者信息

Forsythe I, Butler R, Berg I, McGuire R

机构信息

University of Leeds; Leeds General Infirmary.

出版信息

Dev Med Child Neurol. 1991 Jun;33(6):524-34. doi: 10.1111/j.1469-8749.1991.tb14917.x.

DOI:10.1111/j.1469-8749.1991.tb14917.x
PMID:1864478
Abstract

Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year. Carbamazepine in moderate dosage adversely affected memory, but sodium valproate and phenytoin did not.

摘要

64例儿童癫痫新病例被随机分配接受卡马西平、苯妥英或丙戊酸钠治疗，并在用药前及之后一年的时间里分三次进行认知测试评估。中等剂量的卡马西平对记忆力有不良影响，但丙戊酸钠和苯妥英没有。

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