Justiniano Hildamari, Berlingeri-Ramos Alma C, Sánchez Jorge L
Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, PR.
Am J Dermatopathol. 2008 Aug;30(4):352-69. doi: 10.1097/DAD.0b013e3181722ef4.
Drug eruptions are common adverse reactions to drug therapy and are a frequent reason for consultation in clinical practice. Even though any medication can potentially cause an adverse cutaneous reaction, some drugs are implicated more commonly than others. Histologically, drugs can elicit a variety of inflammatory disease patterns in the skin and panniculus, no pattern being specific for a particular drug. The most common pattern elicited by systemically administered medications is the perivascular pattern. Psoriasiform or granulomatous patterns are rarely caused by medications. The usual histologic patterns of drug eruptions are discussed in this review using the basic patterns of inflammatory diseases. Clinicopathologic correlation is established for relevant patterns. However, the changes of drug-induced skin disease must be made considering clinical presentation, histopathological analysis, and course of the disease.
药物疹是药物治疗常见的不良反应，也是临床实践中患者前来咨询的常见原因。尽管任何药物都有可能引起皮肤不良反应，但有些药物比其他药物更常引发此类反应。从组织学角度来看，药物可在皮肤和皮下组织引发多种炎症性疾病模式，没有哪种模式是特定药物所特有的。全身用药引发的最常见模式是血管周围模式。银屑病样或肉芽肿性模式很少由药物引起。本综述使用炎症性疾病的基本模式来讨论药物疹的常见组织学模式。针对相关模式建立了临床病理相关性。然而，必须结合临床表现、组织病理学分析和疾病病程来判断药物性皮肤病的变化。
