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非那雄胺引起的银屑病样药疹：一种常用药物的罕见副作用。

Psoriasiform Drug Eruption to Finasteride: Uncommon Side Effect of a Commonly Used Drug.

作者信息

Muddebihal Aishwarya, Khurana Ananta, Kulhari Anita, Ahuja Arvind

机构信息

Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. RML Hospital, New Delhi, India.

Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. RML Hospital, New Delhi, India.

出版信息

Int J Trichology. 2022 Nov-Dec;14(6):216-217. doi: 10.4103/ijt.ijt_42_21. Epub 2023 Jan 31.

DOI:10.4103/ijt.ijt_42_21
PMID:37034544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10075345/
Abstract

Finasteride, a 5-α reductase inhibitor, is generally well tolerated on long-term use and cutaneous adverse events have rarely been observed with the drug. We present the case of a 25-year-old male who developed an extensive psoriasiform eruption within a week of starting finasteride 1 mg for androgenetic alopecia.

摘要

非那雄胺是一种5-α还原酶抑制剂，长期使用时一般耐受性良好，很少观察到该药物引起的皮肤不良事件。我们报告了一例25岁男性病例，该患者在开始服用1毫克非那雄胺治疗雄激素性脱发一周内出现了广泛的银屑病样皮疹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58c/10075345/04fc61718d72/IJT-14-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58c/10075345/1517f88c67b9/IJT-14-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58c/10075345/04fc61718d72/IJT-14-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58c/10075345/1517f88c67b9/IJT-14-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58c/10075345/04fc61718d72/IJT-14-216-g002.jpg

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Psoriasiform Drug Eruption to Finasteride: Uncommon Side Effect of a Commonly Used Drug.非那雄胺引起的银屑病样药疹：一种常用药物的罕见副作用。
Int J Trichology. 2022 Nov-Dec;14(6):216-217. doi: 10.4103/ijt.ijt_42_21. Epub 2023 Jan 31.
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本文引用的文献

1
Psoriasis provoked or exacerbated by medications: identifying culprit drugs.药物诱发或加重的银屑病：识别致病药物
JAMA Dermatol. 2014 Sep;150(9):963. doi: 10.1001/jamadermatol.2014.1019.
2
T cell-mediated acute localized exanthematous pustulosis caused by finasteride.由非那雄胺引起的 T 细胞介导的急性局限性发疹性脓疱病。
J Allergy Clin Immunol. 2012 Feb;129(2):589-94. doi: 10.1016/j.jaci.2011.07.033. Epub 2011 Aug 24.
3
The role of drugs in the induction and/or exacerbation of psoriasis.药物在诱导和/或加重银屑病中的作用。
Int J Dermatol. 2010 Dec;49(12):1351-61. doi: 10.1111/j.1365-4632.2010.04570.x.
4
Urticarial rush due to finasteride.非那雄胺引起的荨麻疹样疹。
Allergy. 2010 Mar;65(3):405-6. doi: 10.1111/j.1398-9995.2009.02165.x. Epub 2009 Oct 8.
5
Solitary fixed drug eruption caused by finasteride.非那雄胺引起的孤立性固定性药疹。
J Am Acad Dermatol. 2009 Jan;60(1):168-9. doi: 10.1016/j.jaad.2008.07.037.
6
Pattern analysis of drug-induced skin diseases.药物性皮肤病的模式分析
Am J Dermatopathol. 2008 Aug;30(4):352-69. doi: 10.1097/DAD.0b013e3181722ef4.
7
Erythema annulare centrifugum secondary to treatment with finasteride.
J Drugs Dermatol. 2007 Apr;6(4):460-3.
8
Finasteride-related cutaneous vaculitis.非那雄胺相关的皮肤血管炎。
Postgrad Med J. 1996 Feb;72(844):127. doi: 10.1136/pgmj.72.844.127-a.