Tanahashi Jin, Kashima Kenji, Daa Tsutomu, Kondoh Yoshiyuki, Yada Naomi, Kuratomi Eiji, Yokoyama Shigeo
Department of Pathology, Faculty of Medicine, Oita University, Yufu-shi, Oita, Japan.
Am J Dermatopathol. 2008 Aug;30(4):408-11. doi: 10.1097/DAD.0b013e31817d2a4a.
Apocrine differentiation is a rare event in sebaceoma, and only 3 cases have been reported. We report a case of sebaceoma with extensive apocrine differentiation on the scalp in a 73-year-old Japanese woman. The resected tumor was located entirely within the dermis and subcutis as a well-circumscribed, lobulated, solid, and partially cystic mass, measuring 35 mm at the largest diameter. Histopathologically, it was composed of uniform basaloid cells with clusters of sebocytes, squamous islands of ductal structures, and apocrine cells with apparent decapitation secretion. Nuclear atypia of all types of cells was inconspicuous, and mitotic figures were infrequent. We considered the lesion to be a sebaceoma with apocrine differentiation.
大汗腺分化在皮脂腺瘤中是一种罕见现象，仅有3例报告。我们报告1例73岁日本女性头皮部具有广泛大汗腺分化的皮脂腺瘤。切除的肿瘤完全位于真皮和皮下组织内，为边界清楚、分叶状、实性且部分呈囊性的肿块，最大直径为35mm。组织病理学上，它由均匀的基底样细胞、皮脂腺细胞簇、导管结构的鳞状上皮岛以及具有明显断头分泌的大汗腺细胞组成。所有类型细胞的核异型性均不明显，有丝分裂象罕见。我们认为该病变是具有大汗腺分化特征性的皮脂腺瘤。
