Angulo Jorge, Jaqueti Gerardo, Kutzner Heinz, Requena Luis
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Avenida Reyes Católicos 2, 28040-Madrid, Spain.
J Cutan Pathol. 2007 Oct;34(10):801-3. doi: 10.1111/j.1600-0560.2006.00709.x.
Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation. The neoplasm is composed of four different types of epithelial cells, including pale or clear cells, polygonal cells, mucinous cells and squamous cells, with variable proportions of them from case to case. In most examples of this neoplasm, clear or the polygonal cells are predominant, whereas the other types of neoplastic cells are less abundant. We report two cases of apocrine hidradenoma mostly composed of squamous cells. Histopathologic examination showed that the neoplasms were composed of both solid and cystic areas. The solid aggregations of neoplastic cells were composed of a peripheral layer of basaloid polygonal cells, whereas squamous cells forming the bulk of the aggregations. These squamous cells showed large eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli. In one case, small foci of mucinous cells could also be seen in some aggregations of neoplastic cells, mostly around ductal structures. In both the cases, some of the tubular structures lined by epithelial cells showed evidence of decapitation secretion in their luminal border. The neoplastic stroma consisted of sclerotic collagen bundles when compared with adjacent normal dermis, and artefactual clefts separated the neoplasms from the surrounding tissue. The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms.
大汗腺腺瘤是一种具有大汗腺分化的良性附属器肿瘤。该肿瘤由四种不同类型的上皮细胞组成，包括淡染或透明细胞、多边形细胞、黏液细胞和鳞状细胞，不同病例中它们的比例各不相同。在该肿瘤的大多数病例中，透明细胞或多边形细胞占主导，而其他类型的肿瘤细胞数量较少。我们报告了两例主要由鳞状细胞组成的大汗腺腺瘤。组织病理学检查显示，肿瘤由实性和囊性区域组成。肿瘤细胞的实性聚集由一层外周的基底样多边形细胞组成，而鳞状细胞构成了聚集物的主体。这些鳞状细胞显示出大的嗜酸性细胞质和泡状核，核仁突出。在其中一例中，在一些肿瘤细胞聚集中也可见小灶黏液细胞，主要围绕导管结构。在这两例中，一些由上皮细胞衬里的管状结构在其管腔边缘显示出断头分泌的证据。与相邻正常真皮相比，肿瘤间质由硬化的胶原束组成，人为裂隙将肿瘤与周围组织分隔开。本报告中描述的罕见病例很特殊，因为大多数肿瘤细胞呈现鳞状外观，因此我们认为鳞状细胞大汗腺腺瘤是这些肿瘤最合适的名称。
