Tsukamoto Y, Kotani T, Shiraishi Y, Kawamura H, Sakuma S
Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka 593, Japan.
Avian Pathol. 1996 Mar;25(1):95-102. doi: 10.1080/03079459608419123.
The time course of cell proliferation of collecting ducts and ureter epithelium in the regenerating process were investigated in 3-week-old chickens inoculated intravenously with nephropathogenic infectious bronchitis virus (IBV). Histopathologically, collecting ducts and ureter epithelia showed severe degenerative changes from 3 to 4 days post-inoculation (p.i.), hyperplasia and hypertrophy by day 8 and had returned to normal by day 10. A labelling index using bromodeoxyuridine showed that the epithelial cell proliferation began from day 3 p.i., reached a maximum at day 6, and returned to normal by day 8. These results indicate that the epithelial cell proliferation of collecting ducts and ureters starts during the degenerative stage and is transiently up-regulated in the regenerating process of IBV-induced nephritis.
对静脉接种肾致病性传染性支气管炎病毒（IBV）的3周龄鸡，研究了再生过程中集合管和输尿管上皮细胞增殖的时间进程。组织病理学检查显示，接种后3至4天，集合管和输尿管上皮出现严重变性改变，第8天出现增生和肥大，第10天恢复正常。使用溴脱氧尿苷的标记指数显示，上皮细胞增殖从接种后第3天开始，第6天达到最大值，第8天恢复正常。这些结果表明，集合管和输尿管的上皮细胞增殖始于变性阶段，并在IBV诱导的肾炎再生过程中短暂上调。
