Kobayashi Y, Horimoto T, Kawaoka Y, Alexander D J, Itakura C
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan.
Avian Pathol. 1996 Jun;25(2):285-304. doi: 10.1080/03079459608419142.
Lesions of chickens inoculated with two highly pathogenic avian influenza virus strains, A/turkey/England/50-92/91 (H5N1) and A/chicken/Victoria/1/85 (H7N7) were examined histologically and immunohistochemically. Birds of both treatment groups died within 5 days post-inoculation. The most significant lesions induced by these two viruses consisted of swelling of the microvascular endothelium, systemic congestion, multifocal haemorrhages, perivascular mononuclear cell infiltration, and thrombosis associated with viral antigen in the vascular endothelium and/or perivascular parenchymatous cells. Viral antigen in the cardiac myocytes was consistently detected in all birds. In addition, severe pulmonary congestion and oedema was found in A/turkey/England/50-92/91 virus-inoculated birds that died within 1 day post-inoculation. The other chickens of both groups showed necrotic and inflammatory changes associated with viral antigen in various organs and tissues. These findings suggested that cardiovascular system involvement played an important role in the pathogenesis of these virus infections.
对接种两种高致病性禽流感病毒株，即A/火鸡/英格兰/50 - 92/91（H5N1）和A/鸡/维多利亚/1/85（H7N7）的鸡的病变进行了组织学和免疫组织化学检查。两个治疗组的鸡在接种后5天内死亡。这两种病毒引起的最显著病变包括微血管内皮肿胀、全身充血、多灶性出血、血管周围单核细胞浸润以及与血管内皮和/或血管周围实质细胞中的病毒抗原相关的血栓形成。在所有鸡中均持续检测到心肌细胞中的病毒抗原。此外，在接种后1天内死亡的接种A/火鸡/英格兰/50 - 92/91病毒的鸡中发现了严重的肺充血和水肿。两组中的其他鸡在各种器官和组织中均表现出与病毒抗原相关的坏死和炎症变化。这些发现表明，心血管系统受累在这些病毒感染的发病机制中起重要作用。
