Goldberg R D, Michelassi F, Montag A G
Department of Pathology, University of Chicago, IL 60637.
Hum Pathol. 1991 Jun;22(6):618-22. doi: 10.1016/0046-8177(91)90243-i.
An immunophenotype was performed on an osteoclast-like giant cell tumor of the pancreas using a panel of antibodies to epithelial and leukocyte antigens. Several antibodies to cytokeratin and carcinoembryonic antigen were negative in the tumor. Osteoclast-like cells were positive for CD4, CD13, CD45, CD68, CD71, and vimentin, but negative for lysozyme and HLA-DR. Mononuclear tumor cells were positive for CD4, CD11c, CD13, CD14, CD45, CD68, CD71, HLA-DR, and vimentin, but negative for lysozyme. The phenotype is similar to that previously described for giant cell tumor of bone. The osteoclast-like cell phenotype is also similar to that reported for normal osteoclasts. The findings support a nonepithelial origin for osteoclast-like giant cell tumor of the pancreas, and suggest a derivation similar to giant cell tumor of bone.
利用一组针对上皮和白细胞抗原的抗体，对胰腺破骨细胞样巨细胞瘤进行了免疫表型分析。几种细胞角蛋白和癌胚抗原抗体在肿瘤中呈阴性。破骨细胞样细胞CD4、CD13、CD45、CD68、CD71和波形蛋白呈阳性，但溶菌酶和HLA - DR呈阴性。单核肿瘤细胞CD4、CD11c、CD13、CD14、CD45、CD68、CD71、HLA - DR和波形蛋白呈阳性，但溶菌酶呈阴性。该表型与先前描述的骨巨细胞瘤相似。破骨细胞样细胞表型也与报道的正常破骨细胞相似。这些发现支持胰腺破骨细胞样巨细胞瘤的非上皮起源，并提示其起源与骨巨细胞瘤相似。
