Hanayneh Wissam, Parekh Hiral, Fitzpatrick Garrett, Feely Michael, George Thomas J, Starr Jason S
Department of Medicine, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida.
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida.
J Pancreat Cancer. 2019 Jul 23;5(1):26-33. doi: 10.1089/pancan.2019.0007. eCollection 2019.
Pancreatic adenocarcinoma remains one of the most lethal malignancies with little treatment advancements. Other less common pancreatic cancer histologies have different outcomes and disease course. In this article, we report two cases of rare pancreatic tumors. The first case is a 59-year old, who was undergoing surveillance of a known pancreatic cyst, which eventually enlarged. The mass was resected and pathology revealed undifferentiated carcinoma with osteoclast-like giant cells. The patient did not receive any adjuvant therapy and has had no recurrence. The second case is of a 60-year-old patient who presented with signs and symptoms of pancreatic insufficiency and was found to have clear cell adenocarcinoma of the pancreas. She received neoadjuvant chemoradiotherapy followed by surgical resection without complications. Our article presents these rare malignancies, which had outcomes that are more encouraging than typical adenocarcinomas. Genomic sequencing can provide more insight into these tumors and potentially provide targets for therapy.
胰腺腺癌仍然是最致命的恶性肿瘤之一，治疗进展甚微。其他不太常见的胰腺癌组织学类型有不同的预后和病程。在本文中，我们报告了两例罕见的胰腺肿瘤病例。第一例是一名59岁患者，正在对已知的胰腺囊肿进行监测，该囊肿最终增大。肿块被切除，病理显示为伴有破骨细胞样巨细胞的未分化癌。该患者未接受任何辅助治疗，也没有复发。第二例是一名60岁患者，表现出胰腺功能不全的体征和症状，被发现患有胰腺透明细胞腺癌。她接受了新辅助放化疗，随后进行了手术切除，未出现并发症。我们的文章介绍了这些罕见的恶性肿瘤，其预后比典型腺癌更令人鼓舞。基因组测序可以为这些肿瘤提供更多见解，并有可能提供治疗靶点。
