Gatteschi B, Saccomanno S, Bartoli F G, Salvi S, Liu G, Pugliese V
Department of Pathology, National Institute for Research on Cancer, Genova, Italy.
Int J Pancreatol. 1995 Oct;18(2):169-75. doi: 10.1007/BF02785891.
The morphological, immunohistochemical, and molecular biological features of a case of giant cell tumor of the pancreas are described. This neoplasm showed mononuclear and multinucleated tumor giant cells as well as numerous osteoclast-like cells with multiple foci of osteoid-osseous metaplasia. The pleomorphic and osteoclastic giant cells displayed extensive homologies in their immunohistochemical profiles. Neither the pleomorphic nor osteoclast-like portion of the tumor showed neither c-Ki-ras nor p53 mutation and did not express the mutated p53 protein. The results suggest that the pleomorphic and osteoclast-like components are histogenetically related and that this rare neoplasm originates from a precursor cell capable of differentiating along divergent cell type.
本文描述了一例胰腺巨细胞瘤的形态学、免疫组织化学及分子生物学特征。该肿瘤显示有单核及多核肿瘤巨细胞，以及众多伴有多处类骨质-骨化生灶的破骨细胞样细胞。多形性巨细胞和破骨细胞样巨细胞在免疫组织化学特征上表现出广泛的同源性。肿瘤的多形性部分和破骨细胞样部分均未显示c-Ki-ras和p53突变，也未表达突变型p53蛋白。结果提示，多形性成分和破骨细胞样成分在组织发生学上相关，且这种罕见肿瘤起源于一种能够沿不同细胞类型分化的前体细胞。
