Ravichandran V, Selvam R
Department of Medical Biochemistry, University of Madras, India.
Indian J Exp Biol. 1991 Jan;29(1):56-8.
Lipidperoxidation in plasma of rats fed with vitamin B-6 deficient diet for a period of 12 weeks was studied with pair-fed controls. Plasma pyridoxal 5'-phosphate, alanine amino transferase and aspartate amino transferase, the markers of vitamin B-6 status, were significantly low in vitamin B-6 deficient rats. Plasma malondialdehyde level, conjugated dienes and lipofuscin like pigments were increased in vitamin B-6 deficiency. Increased levels of plasma lipids, calcium, iron and copper were observed in vitamin B-6 deficiency. Plasma susceptibility to lipidperoxidation was maximal in vitamin B-6 deficiency, upon stimulation by the promotors, Fe2+, Fe3+, Cu2+, ascorbate, t-butyl hydroperoxide and hydrogen peroxide.
对喂食缺乏维生素B-6饮食12周的大鼠血浆中的脂质过氧化进行了研究，并设置了配对喂养的对照组。维生素B-6缺乏的大鼠中，作为维生素B-6状态标志物的血浆5'-磷酸吡哆醛、丙氨酸氨基转移酶和天冬氨酸氨基转移酶显著降低。维生素B-6缺乏时，血浆丙二醛水平、共轭二烯和类脂褐素样色素增加。维生素B-6缺乏时，观察到血浆脂质、钙、铁和铜水平升高。在维生素B-6缺乏时，经Fe2+、Fe3+、Cu2+、抗坏血酸盐、叔丁基过氧化氢和过氧化氢等促氧化剂刺激后，血浆脂质过氧化的敏感性最高。
