Stefańska Joanna, Struga Marta, Tyski Stefan, Kossakowski Jerzy, Dobosz Maria
Department of Pharmaceutical Microbiology, Medical University, Warsaw, Poland.
Pol J Microbiol. 2008;57(2):179-82.
Antibacterial and antifungal activity of 2,4-dihydro- [1,2,4]triazol-3-one derivatives were examined by the disc-diffusion method (growth inhibition zone diameter in agar medium). The MIC's for the most active agents were determined. Of all the tested compounds, aminomethyl derivatives of 2,4-dihydro-[1,2,4]triazol-3-one exhibit activity against the majority of microorganisms studied.
采用纸片扩散法（琼脂培养基中的生长抑制圈直径）检测了2,4-二氢-[1,2,4]三唑-3-酮衍生物的抗菌和抗真菌活性。测定了最具活性药物的最低抑菌浓度（MIC）。在所有测试化合物中，2,4-二氢-[1,2,4]三唑-3-酮的氨甲基衍生物对大多数所研究的微生物具有活性。
