Asnani M, Lipps G, Reid M
Sickle Cell Unit, Tropical Medicine Research Institute, The University of the West Indies, Kingston 7, Jamaica, West Indies.
West Indian Med J. 2007 Dec;56(6):491-7.
Sickle cell disease (SCD) is the commonest genetic disorder in Jamaica and greatly affects the quality of life (QOL) of those who are afflicted. The Short Form 36 survey (SF-36) questionnaire is one of the most commonly utilized measures of QOL. Physicians cannot interpret QOL measures until the instruments being used to make assessment are adequately established in their population. The Jamaican cultural and educational systems expose its people to many stresses which likely impact on their QOL. It is thus postulated that the QOL construct may exhibit a different structure for the population with sickle cell disease.
The SF-36 v.2 was interviewer administered to the Jamaican Sickle Cell Disease Cohort Study participants ('Cohort' sample) and a random sample of adult sickle cell unit patients ('Main'sample). Demographic data were also collected on both groups. Both of the samples did not meet the five rule criteria for compliance with the original SF-36 component structure. Hence, principal components analysis was used to determine the component structure of the SF-36 in both groups.
Three dimensions may underlie the SF-36 for both groups and these could be labelled 'Physical Health', 'Mental Health' and 'Role Limitations'. This solution accounted for 45.8% of the variability underlying the SF-36 in the 'Cohort'sample and 54.6% of the variability in the 'Main' sample.
It concluded that within Jamaican samples of patients with sickle cell disease, the SF-36 has a component structure which is quite distinct from that initially proposed by its creators.
镰状细胞病（SCD）是牙买加最常见的遗传疾病，严重影响患者的生活质量（QOL）。简明健康状况调查问卷（SF - 36）是最常用的生活质量测量工具之一。在用于评估的工具在其目标人群中得到充分验证之前，医生无法解读生活质量测量结果。牙买加的文化和教育体系使人们面临许多压力，这可能会影响他们的生活质量。因此，推测生活质量结构在镰状细胞病患者群体中可能呈现出不同的结构。
对牙买加镰状细胞病队列研究的参与者（“队列”样本）以及成年镰状细胞病科室患者的随机样本（“主要”样本）采用访谈方式进行SF - 36 v.2问卷调查。同时收集了两组的人口统计学数据。两个样本均不符合原始SF - 36分量结构的五条合规标准。因此，采用主成分分析来确定两组中SF - 36的分量结构。
两组中SF - 36可能基于三个维度，可分别标记为“身体健康”、“心理健康”和“角色限制”。该解决方案在“队列”样本中解释了SF - 36潜在变异性的45.8%，在“主要”样本中解释了54.6%的变异性。
得出结论，在牙买加镰状细胞病患者样本中，SF - 36的分量结构与最初开发者提出的结构有很大不同。
