Najafizadeh K, Ghorbani F, Farnia P, Shiehmorteza M, Jamali M
National Research Institute of Tuberculosis and Lung Diseases, Department of Pulmonary Medicine, Masih Daneshvari Hospital, Darabad, Tehran, Iran.
Int J Tuberc Lung Dis. 2008 Aug;12(8):962-6.
Mycobacterium tuberculosis infection has been shown to be associated with anthracotic bronchitis. However, the typical manifestation of infection is not usually present in infected patients, which raises the question of whether a particular strain of M. tuberculosis is associated with this group of patients.
To determine whether a particular strain of M. tuberculosis is associated with anthracotic bronchitis.
We assessed the predominant space oligonucleotide (spoligotype) patterns of M. tuberculosis complex isolated from patients with anthracotic bronchitis and compared the results with tuberculosis (TB) subtype patterns in Iran and other countries.
During a 7-month period (April--October 2006), we enrolled 87 patients (30 men and 57 women) with anthracotic bronchitis, 26% (n = 23) of whom had TB. Spoligotyping of M. tuberculosis among these 23 patients showed four distinct patterns: East-African-Indian (11, 47.8%) and Central-Asian (7, 30.4%), Haarlem I (4, 17.4%) and T-1 (1, 4.3%). When compared with spoligotype patterns of M. tuberculosis in Middle Eastern countries, including Iran, anthracotic bronchitis had similar patterns.
Our results indicate that the atypical manifestations of TB in anthracotic patients are not caused by any particular subtypes of M. tuberculosis. We conclude that anthracotic bronchitis is actually an atypical presentation of tuberculous infection with common subtypes inside the bronchial mucosa.
已表明结核分枝杆菌感染与炭末沉着性支气管炎有关。然而，感染的典型表现通常在受感染患者中并不存在，这就提出了一个问题，即结核分枝杆菌的特定菌株是否与这组患者有关。
确定结核分枝杆菌的特定菌株是否与炭末沉着性支气管炎有关。
我们评估了从炭末沉着性支气管炎患者中分离出的结核分枝杆菌复合群的主要间隔寡核苷酸（spoligotype）模式，并将结果与伊朗和其他国家的结核病（TB）亚型模式进行了比较。
在7个月期间（2006年4月至10月），我们纳入了87例炭末沉着性支气管炎患者（30例男性和57例女性），其中26%（n = 23）患有结核病。这23例患者中结核分枝杆菌的spoligotyping显示出四种不同模式：东非 - 印度型（11例，47.8%）、中亚型（7例，30.4%）、哈勒姆I型（4例，17.4%）和T - 1型（1例，4.3%）。与包括伊朗在内的中东国家结核分枝杆菌的spoligotype模式相比，炭末沉着性支气管炎具有相似模式。
我们的结果表明，炭末沉着性患者中结核病的非典型表现并非由结核分枝杆菌的任何特定亚型引起。我们得出结论，炭末沉着性支气管炎实际上是支气管黏膜内常见亚型结核感染的非典型表现。
