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Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer.

作者信息

Seenath M M, Roberts D, Cawthorne C, Saunders M P, Armstrong G R, O'Dwyer S T, Stratford I J, Dive C, Renehan A G

机构信息

Clinical and Experimental Pharmacology, Paterson Institute of Cancer Research, Manchester, UK.

出版信息

Br J Cancer. 2008 Aug 5;99(3):459-63. doi: 10.1038/sj.bjc.6604474. Epub 2008 Jul 22.

DOI:10.1038/sj.bjc.6604474
PMID:18648372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2527799/
Abstract

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2efa/2527799/f53a6de7b506/6604474f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2efa/2527799/2599ad46d743/6604474f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2efa/2527799/f53a6de7b506/6604474f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2efa/2527799/2599ad46d743/6604474f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2efa/2527799/f53a6de7b506/6604474f2.jpg

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Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.Tax 通过抑制 Bid 和 Bim 的表达使 HTLV-1 感染的 T 细胞产生抗细胞凋亡作用。
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