白细胞去除术治疗活动性袋炎：一项初步研究。
Leukocytapheresis for the treatment of active pouchitis: a pilot study.
作者信息
Araki Yasumi, Mitsuyama Keiichi, Nagae Takaaki, Tou Yuji, Nakagawa Motonori, Iwatani Yasue, Harada Masakazu, Ozasa Hiroyuki, Sata Michio, Noake Toshihiro
机构信息
Kurume Coloproctology Center, Kurume, Japan.
出版信息
J Gastroenterol. 2008;43(7):571-5. doi: 10.1007/s00535-008-2199-0. Epub 2008 Jul 23.
BACKGROUND
Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.
METHODS
Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy.
RESULTS
Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8-10) to 4.0 (range, 2-8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed.
CONCLUSIONS
Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial.
背景
袋炎是溃疡性结肠炎回肠储袋肛管吻合术的一种主要长期并发症。本研究的目的是探讨白细胞去除术治疗活动性袋炎的疗效。
方法
8例活动性袋炎患者在开放标签治疗方案中每周接受1次白细胞去除术，共进行5周，并联合基线治疗。
结果
患者的袋炎疾病活动指数评分显著改善，从9.5（范围8 - 10）降至4.0（范围2 - 8）（P < 0.05）。8例接受治疗的患者中有6例（75%）实现缓解。未观察到不良事件。
结论
白细胞去除术治疗可能是溃疡性结肠炎回肠储袋肛管吻合术后袋炎患者的一种新治疗策略。这些令人鼓舞的结果促使我们开展一项随机对照试验。
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