Kim Ekyune, Yamashita Misuzu, Kimura Masanori, Honda Arata, Kashiwabara Shin-Ichi, Baba Tadashi
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan.
Int J Dev Biol. 2008;52(5-6):677-82. doi: 10.1387/ijdb.072528ek.
Mammalian fertilization requires sperm to penetrate the cumulus mass and egg zona pellucida prior to fusion with the egg. Although sperm penetration through these physical barriers is essential, the molecular mechanism has not yet been completely elucidated. In addition to sperm motility, hyaluronan-hydrolyzing and proteolytic enzymes of sperm have been suggested to participate in the penetration events. Here we focus on the functional roles of hyaluronidase and protease in sperm passage through the cumulus mass and zona pellucida.
哺乳动物受精需要精子在与卵子融合之前穿透卵丘细胞团和透明带。虽然精子穿透这些物理屏障至关重要，但其分子机制尚未完全阐明。除了精子活力外，精子的透明质酸水解酶和蛋白水解酶也被认为参与了穿透过程。在此，我们重点关注透明质酸酶和蛋白酶在精子穿过卵丘细胞团和透明带过程中的功能作用。
