Sasakawa Tomoki, Iwasaki Hiroshi
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa 078-8510.
Masui. 2008 Jul;57(7):860-8.
A full stomach patient often requires a rapid sequence induction (RSI) technique to protect against gastric aspiration. Suxamethonium is the most common muscle relaxant used because it has a fast onset and a short duration. Unfortunately it can have serious side effects as a result of its membrane depolarizing effect and release of potassium. Rocuronium has been suggested to create intubating conditions similar to suxamethonium. However, it has been proved that suxamethonium creates superior intubation conditions to rocuronium in a large meta-analysis comparing intubation conditions. Once Org 25969 (sugammadex) is available to rapidly bind rocuronium and reverse its action, rocuronium may replace succinylcholine for rapid-sequence induction.
饱腹患者通常需要采用快速序贯诱导（RSI）技术以防止胃内容物误吸。琥珀胆碱是最常用的肌肉松弛剂，因为其起效快、作用时间短。不幸的是，由于其膜去极化作用和钾离子释放，它可能会产生严重的副作用。有人提出罗库溴铵可产生与琥珀胆碱相似的插管条件。然而，在一项比较插管条件的大型荟萃分析中已证明，琥珀胆碱产生的插管条件优于罗库溴铵。一旦org 25969（舒更葡糖钠）可用于快速结合罗库溴铵并逆转其作用，罗库溴铵可能会取代琥珀胆碱用于快速序贯诱导。
