Department of Anesthesiology, American University of Beirut, Lebanon.
Anaesthesia. 2010 Apr;65(4):358-61. doi: 10.1111/j.1365-2044.2010.06243.x.
This study investigates the effect of suxamethonium vs rocuronium on the onset of haemoglobin desaturation during apnoea, following rapid sequence induction of anaesthesia. Sixty patients were randomly allocated to one of three groups. Anaesthesia was induced with lidocaine 1.5 mg.kg(-1), fentanyl 2 microg.kg(-1) and propofol 2 mg.kg(-1), followed by either rocuronium 1 mg.kg(-1) (Group R) or suxamethonium 1.5 mg.kg(-1) (Group S). The third group received propofol 2 mg.kg(-1) and suxamethonium 1.5 mg.kg(-1) only (Group SO). The median (IQR [range]) time to reach S(p)O(2) of 95% was significantly shorter in Group S (358 (311-373 [245-430]) s) [corrected] than in Group R (378 (370-393 [366-420]) s; p = 0.003), and shorter in Group SO (242 (225-258 [189-270]) s) [corrected] than in both Group R (p < 0.001) and Group S (p < 0.001). When suxamethonium is administered for rapid sequence induction of anaesthesia, a faster onset of oxygen desaturation is observed during the subsequent apnoea compared with rocuronium. However, time to desaturation is prolonged whenever lidocaine and fentanyl precede suxamethonium.
这项研究调查了琥珀酰胆碱与罗库溴铵对快速序贯诱导麻醉后呼吸暂停期间血红蛋白饱和度降低的影响。将 60 名患者随机分配到三组之一。麻醉诱导使用利多卡因 1.5mg/kg、芬太尼 2μg/kg 和丙泊酚 2mg/kg，然后给予罗库溴铵 1mg/kg（R 组）或琥珀酰胆碱 1.5mg/kg（S 组）。第三组仅给予丙泊酚 2mg/kg 和琥珀酰胆碱 1.5mg/kg（SO 组）。达到 95%SpO2 的中位数（IQR [范围]）时间在 S 组（358 [311-373 [245-430]）s）[校正]显著短于 R 组（378 [370-393 [366-420]）s；p=0.003），并且在 SO 组（242 [225-258 [189-270]）s）[校正]短于 R 组（p<0.001）和 S 组（p<0.001）。在快速序贯诱导麻醉时给予琥珀酰胆碱，与罗库溴铵相比，随后的呼吸暂停期间观察到氧饱和度降低更快。然而，无论何时利多卡因和芬太尼先于琥珀酰胆碱，饱和度降低的时间都会延长。
